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Coronary heart disease risk assessment and characterization of coronary artery disease using coronary CT angiography: Comparison of asymptomatic and symptomatic groups

Title
Coronary heart disease risk assessment and characterization of coronary artery disease using coronary CT angiography: Comparison of asymptomatic and symptomatic groups
Authors
Hwang Y.Kim Y.Chung I.-M.Ryu J.Park H.
Ewha Authors
정익모박혜숙김유경
SCOPUS Author ID
정익모scopus; 박혜숙scopus; 김유경scopus
Issue Date
2010
Journal Title
Clinical Radiology
ISSN
0009-9260JCR Link
Citation
vol. 65, no. 8, pp. 601 - 608
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
AIM: To evaluate the prevalence of coronary artery disease (CAD) in relation to risk of coronary heart disease (CHD) and assess plaque characteristics from coronary computed tomography (CT) angiography in asymptomatic and symptomatic patients. MATERIALS AND METHODS: Three hundred and ninety consecutive patients [asymptomatic group, n =138; symptomatic group (atypical or non-anginal chest pain), n =252] were retrospectively enrolled. They were subsequently classified into three CHD risk categories, based on the National Cholesterol Education Program guidelines, and 10 year risks of coronary events were calculated using Framingham risk score. CT was evaluated for stenosis, plaque composition, and coronary calcium scores. RESULTS: CAD was observed in 42% of the asymptomatic group and 62% of the symptomatic group. In the former, the prevalence of CAD in low-, moderate- and high-risk subgroups was 21.4, 47.4 and 65%, respectively, and was 33.3, 74.4, and 72.4% in the symptomatic group. Framingham 10-year risks of coronary events were significantly higher in patients with CAD than in normal participants, and receiver operating characteristics curves showed that discriminatory power was poor in the asymptomatic group and symptomatic men, and good in symptomatic women. Of the participants in the asymptomatic group, 12% exhibited only noncalcified plaques and of the symptomatic group, 7% exhibited only non-calcified plaques. The coronary calcium score was significantly higher for significant stenosis than for non-significant stenosis in both groups. CONCLUSIONS: The prevalence of CAD was not negligible even in subgroups with low-tomoderate CHD risk. Additionally, the Framingham risk score was effective for predicting CAD only in symptomatic women. Coronary calcium scores correlated with significant stenosis; however, a sizeable percentage of both groups had only non-calcified plaques. © 2010 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.
DOI
10.1016/j.crad.2010.04.009
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의학전문대학원 > 의학과 > Journal papers
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