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dc.contributor.author한평림-
dc.date.accessioned2016-08-28T12:08:34Z-
dc.date.available2016-08-28T12:08:34Z-
dc.date.issued2010-
dc.identifier.issn0378-8741-
dc.identifier.otherOAK-6801-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/220976-
dc.description.abstractEthnopharmacological relevance: The oriental medicine Jangwonhwan, which is a boiled extract of 12 medicinal herbs/mushroom, has been prescribed for patients with cognitive dysfunction. Recently, a modified recipe of Jangwonhwan (LMK02-Jangwonhwan) consisting of seven medicinal plants/mushroom, was shown to have a therapeutic potential to ameliorate AD-like pathology. Aim of the study: It was investigated whether a further reduction of Jangwonhwan (LMK03-Jangwonhwan) retains the potency to suppress the AD-like pathology. Materials and Methods: The transgenic mice of Alzheimer disease, Tg-APPswe/PS1dE9, were fed LMK03-Jangwonhwan consisting of two of the herbs, white Poria cocos (Schw.) Wolf and Angelica gigas Nakai, which could protect the AD-like pathology at 300. mg/kg/day of dose for 3 months. In vitro cell biological study, immunohistological and ELISA (enzyme-linked immunosorbent assay) analyses were used to assess its neuroprotective effects against Aβ-induced cell death, and the Aβ accumulation and plaque deposition in the brain. Results: In vitro study with SH-SY5Y neuroblastoma cells showed that LMK03-Jangwonhwan could protect from cytotoxicity induced by hydrogen peroxide or oligomeric Aβ1-42. Tg-APPswe/PS1dE9 mice were administered LMK03-Jangwonhwan at 300mg/kg/day for 3 months from 4.5 months of age. Immunohistological and ELISA analyses showed that LMK03-Jangwonhwan partially reduced Aβ1-42 and Aβ1-40 levels and β-amyloid plaque deposition in the brain of Tg-APPswe/PS1dE9 mice. However, LMK03-Jangwonhwan poorly suppressed accumulation of reactive oxidative stress in the hippocampus of Tg-APPswe/PS1dE9 mice and inefficiently improved the expression of phospho-CREB and calbindin, the cellular factors that were down-regulated in AD-like brains. Conclusions: These results suggest that LMK03-Jangwonhwan has a potency to inhibit AD-like pathology at a detectable level, but LMK03 is not likely to retain the major ability of LMK02-Jangwonhwan to modify AD pathology in several AD-related molecular parameters. © 2010.-
dc.languageEnglish-
dc.titleA modified preparation (LMK03) of the oriental medicine Jangwonhwan reduces Aβ1-42 level in the brain of Tg-APPswe/PS1dE9 mouse model of Alzheimer disease-
dc.typeArticle-
dc.relation.issue3-
dc.relation.volume130-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage578-
dc.relation.lastpage585-
dc.relation.journaltitleJournal of Ethnopharmacology-
dc.identifier.doi10.1016/j.jep.2010.05.055-
dc.identifier.wosidWOS:000280869900018-
dc.identifier.scopusid2-s2.0-77954954791-
dc.author.googleSeo J.-S.-
dc.author.googleJung E.-Y.-
dc.author.googleKim J.-H.-
dc.author.googleLyu Y.-S.-
dc.author.googleHan P.-L.-
dc.author.googleKang H.-W.-
dc.contributor.scopusid한평림(7201947605)-
dc.date.modifydate20170601143155-
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일반대학원 > 뇌·인지과학과 > Journal papers
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