Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 정낙신 | - |
dc.contributor.author | 최원준 | - |
dc.date.accessioned | 2016-08-28T12:08:34Z | - |
dc.date.available | 2016-08-28T12:08:34Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0250-7005 | - |
dc.identifier.other | OAK-6796 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/220971 | - |
dc.description.abstract | Background: Human A3 adenosine receptor (A3AR) plays an essential role in several physiopathological processes. Thus far, A 3AR-selective ligands have been evaluated as anti-inflammation and anticancer therapeutic agents. Among these ligands, truncated thio-Cl-IB-MECA is a newly reported antagonist, and its function has not been studied. Materials and Methods: Cell viability was measured by MTS assay. Cell cycle progression was analysed by propidium iodide (PI) flow cytometric assay. The apoptotic effects were investigated by Hoechst staining and annexin V-FITC/PI staining. The signal-transduction mechanism was explored by Western blot. Results: Truncated thio-Cl-IB-MECA induced the growth arrest of T24 cells at sub-G 1 phase and provoked apoptosis but not necrosis. Apoptotic death was mediated by the activation of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK). Conclusion: Since truncated thio-Cl-IB-MECA induces anti-proliferation and apoptotic effects via ERK and JNK activation, it may function as an anticancer agent in human bladder cancer cells. | - |
dc.language | English | - |
dc.title | A3 adenosine receptor antagonist, truncated thio-Cl-IB-MECA, induces apoptosis in T24 human bladder cancer cells | - |
dc.type | Article | - |
dc.relation.issue | 7 | - |
dc.relation.volume | 30 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 2823 | - |
dc.relation.lastpage | 2830 | - |
dc.relation.journaltitle | Anticancer Research | - |
dc.identifier.wosid | WOS:000280796400047 | - |
dc.identifier.scopusid | 2-s2.0-77955819668 | - |
dc.author.google | Kim H. | - |
dc.author.google | Kang J.W. | - |
dc.author.google | Lee S. | - |
dc.author.google | Choi W.J. | - |
dc.author.google | Jeong L.S. | - |
dc.author.google | Yang Y. | - |
dc.author.google | Hong J.T. | - |
dc.author.google | Yoon D.Y. | - |
dc.contributor.scopusid | 정낙신(16028528200) | - |
dc.contributor.scopusid | 최원준(55732412300;57211762651) | - |
dc.date.modifydate | 20230627112239 | - |