Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김영주 | * |
dc.date.accessioned | 2016-08-28T12:08:31Z | - |
dc.date.available | 2016-08-28T12:08:31Z | - |
dc.date.issued | 2010 | * |
dc.identifier.issn | 0015-0282 | * |
dc.identifier.other | OAK-6765 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/220946 | - |
dc.description.abstract | Objective: To assess whether the differential sperm tail swelling patterns observed following hypo-osmotic shock are useful in discriminating normal sperm from aneuploid sperm. Design: Prospective study. Setting: University research setting. Intervention(s): Fluorescence in situ hybridization (FISH) was combined with hypo-osmotic swelling for a simultaneous assessment of aneuploidy and viability in human spermatozoa. Main Outcome Measure(s): FISH for chromosomes 1, 13, 18, 21, X, and Y after hypo-osmotic stress was used to investigate the distribution of sperm aneuploidy related to sperm-tail swelling patterns. A total of 16,473 sperm cells were scored from three normal fertile donors and six oligoasthenoteratozoospermic (OAT) patients. Result(s): There was a 17.2-fold decrease in the frequency of total aneuploidy in the sperm with a tail-tip swelling pattern compared with the initial nonselected sperm in the OAT patients. Strikingly, when the sperm with tail-tip swelling patterns were screened from the patients, the frequency of total aneuploidy was actually lower by a factor of four than in the nonselected sperm from fertile donors. Conclusion(s): The sperm cells with tail-tip swelling patterns are related to a low frequency of aneuploidy. © 2010 by American Society for Reproductive Medicine. | * |
dc.language | English | * |
dc.title | Numerical chromosome abnormalities are associated with sperm tail swelling patterns | * |
dc.type | Article | * |
dc.relation.issue | 3 | * |
dc.relation.volume | 94 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 1012 | * |
dc.relation.lastpage | 1020 | * |
dc.relation.journaltitle | Fertility and Sterility | * |
dc.identifier.doi | 10.1016/j.fertnstert.2009.04.043 | * |
dc.identifier.wosid | WOS:000280407900028 | * |
dc.identifier.scopusid | 2-s2.0-77955586683 | * |
dc.author.google | Pang M.-G. | * |
dc.author.google | You Y.-A. | * |
dc.author.google | Park Y.-J. | * |
dc.author.google | Oh S.-A. | * |
dc.author.google | Kim D.-S. | * |
dc.author.google | Kim Y.-J. | * |
dc.contributor.scopusid | 김영주(55801681000) | * |
dc.date.modifydate | 20240415132200 | * |