Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 황은숙 | * |
dc.date.accessioned | 2016-08-28T12:08:31Z | - |
dc.date.available | 2016-08-28T12:08:31Z | - |
dc.date.issued | 2010 | * |
dc.identifier.issn | 0253-6269 | * |
dc.identifier.other | OAK-6764 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/220945 | - |
dc.description.abstract | Pinusolide and its derivative, 15-methoxypinusolidic acid (15-MPA) are diterpenoid compounds isolated from Biota orientalis, which has been used as a Korean folk medicine for treating inflammatory disorders. Pinusolide and 15-MPA suppress nitric oxide generation by suppressing inducible nitric oxide synthase and exerted anti-inflammatory functions, whereas other functions and regulatory mechanisms are largely unknown. In this study, we investigated whether pinusolide and 15-MPA modulate adipocyte differentiation from pre-adipocytes 3T3-L1 cells. We found that 15-MPA, not pinusolide, suppressed adipocyte differentiation in a dose-dependent manner, as revealed by lipid droplet formation and expression of adipogenic genes such as adiponectin and aP2. 15-MPA did not affect mRNA and protein levels of PPARγ, a key adipogenic transcription factor, whereas transcriptional activity of PPARγ was significantly attenuated by 15-MPA. While aP2 promoter activity was increased by ectopic overexpression of PPARγ or by rosiglitazone-induced endogenous PPARγ activation, PPARγ-induced aP2 promoter activity was inhibited in the presence of 15-MPA. These results suggest that 15-MPA suppresses adipocyte differentiation through the inhibition of PPARγ-dependent adipogenic gene expression. © 2010 The Pharmaceutical Society of Korea and Springer Netherlands. | * |
dc.language | English | * |
dc.title | Suppression of adipocyte differentiation by 15-methoxypinusolidic acid through inhibition of PPARγ activity | * |
dc.type | Article | * |
dc.relation.issue | 7 | * |
dc.relation.volume | 33 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 1035 | * |
dc.relation.lastpage | 1041 | * |
dc.relation.journaltitle | Archives of Pharmacal Research | * |
dc.identifier.doi | 10.1007/s12272-010-0709-0 | * |
dc.identifier.wosid | WOS:000280376400010 | * |
dc.identifier.scopusid | 2-s2.0-77955410474 | * |
dc.author.google | Lee Y.S. | * |
dc.author.google | Sung S.H. | * |
dc.author.google | Hong J.-H. | * |
dc.author.google | Hwang E.S. | * |
dc.contributor.scopusid | 황은숙(8688011100) | * |
dc.date.modifydate | 20240123102458 | * |