Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 정성애 | * |
dc.date.accessioned | 2016-08-28T12:08:28Z | - |
dc.date.available | 2016-08-28T12:08:28Z | - |
dc.date.issued | 2010 | * |
dc.identifier.issn | 1043-4666 | * |
dc.identifier.other | OAK-6735 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/220922 | - |
dc.description.abstract | Helicobacter pylori (H. pylori) is an important risk factor of gastric adenocarcinoma. Interleukin (IL)-8 is a potent angiogenic factor and plays an important role in inflammation of gastric mucosa by H. pylori. Host susceptibility may help to predict H. pylori-infected individuals with a higher risk of gastric adenocarcinoma. The aim of this study was to clarify the effect of IL-8 polymorphism on angiogenesis in the process of gastric carcinogenesis in H. pylori-infected Koreans. The IL-8-251A/T polymorphism was genotyped by PCR-RFLP from a total of 395 subjects; 92 normal controls, 87 H. pylori-infected controls, 108 chronic atrophic gastritis and/or intestinal metaplasia and 108 adenocarcinoma. The gastric mucosal concentrations of IL-8, membrane metalloproteinase (MMP)-9, angiopoietin (Ang)-1, and vascular endothelial growth factor (VEGF) were measured by ELISA. MMP-9 concentrations were increased with disease progression. There was significant correlation between MMP-9 and disease progression in AA (r= 0.42, p<0.01) and AT genotype (r= 0.43, p<0.01). Ang-1 concentrations were increased in AA genotype (r= 0.40, p= 0.01). However, there was no significant correlation between VEGF and disease progression in AA genotype. In conclusion, IL-8-251 AA genotype may be associated with angiogenesis in gastric carcinogenesis in H. pylori-infected Koreans. © 2010 Elsevier Ltd. | * |
dc.language | English | * |
dc.title | The interleukin-8-251 AA genotype is associated with angiogenesis in gastric carcinogenesis in Helicobacter pylori-infected Koreans | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 51 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 158 | * |
dc.relation.lastpage | 165 | * |
dc.relation.journaltitle | Cytokine | * |
dc.identifier.doi | 10.1016/j.cyto.2010.05.001 | * |
dc.identifier.wosid | WOS:000280027700008 | * |
dc.identifier.scopusid | 2-s2.0-77954084304 | * |
dc.author.google | Song J.H. | * |
dc.author.google | Kim S.G. | * |
dc.author.google | Jung S.-A. | * |
dc.author.google | Lee M.K. | * |
dc.author.google | Jung H.C. | * |
dc.author.google | Song I.S. | * |
dc.contributor.scopusid | 정성애(7403676915) | * |
dc.date.modifydate | 20240415140437 | * |