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Anti-scratching behavioral effects of n-stearoyl-phytosphingosine and 4-hydroxysphinganine in mice

Title
Anti-scratching behavioral effects of n-stearoyl-phytosphingosine and 4-hydroxysphinganine in mice
Authors
Ryu K.-R.Lee B.Lee I.-A.Oh S.Kim D.-H.
Ewha Authors
오세관
SCOPUS Author ID
오세관scopus
Issue Date
2010
Journal Title
Lipids
ISSN
0024-4201JCR Link
Citation
vol. 45, no. 7, pp. 613 - 618
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
N-Stearoyl-phytosphingosine (SPS) and 4-hydroxysphinganine (phytosphingosine, PS), which are sphingolipids frequently found in mammalian skin, plants, and yeast, have been used as ingredients in cosmetics. In mice, treatment with SPS and PS inhibited histamine-induced scratching behavior and vascular permeability. These agents inhibited the expression of the allergic cytokines, IL-4 and TNF-α, and the activation of the transcription factors, NF-κB and c-jun, in histamine-stimulated skin tissues. These agents also showed potent anti-histamine effects in the Magnus test using guinea pig ileum. Based on these results, SPS and PS may improve scratching behavioral reactions in skin by regulating the action of histamine and the activation of the transcription factors NF-κB and c-jun. © 2010 AOCS.
DOI
10.1007/s11745-010-3441-0
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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