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Wine drinking and epithelial ovarian cancer risk: A meta-analysis

Title
Wine drinking and epithelial ovarian cancer risk: A meta-analysis
Authors
Kim H.S.Kim J.W.Shouten L.J.Larsson S.C.Chung H.H.Kim Y.B.Ju W.Park N.H.Song Y.S.Kim S.C.Kang S.-B.
Ewha Authors
김승철주웅
SCOPUS Author ID
김승철scopus; 주웅scopus
Issue Date
2010
Journal Title
Journal of Gynecologic Oncology
ISSN
2005-0380JCR Link
Citation
vol. 21, no. 2, pp. 112 - 118
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
Objective: Wine has been the focus in the prevention of epithelial ovarian cancer (EOC) development because resveratrol abundant in wine has anti-carcinogenic properties. However, epidemiologic results have been heterogenous in the chemopreventive effect of wine on the development of EOC. Thus, we performed a meta-analysis for comparing EOC risk between wine and never drinkers using previous related studies. Methods: After extensive search of the literature between January 1986 and December 2008, we analyzed 10 studies (3 cohort and 7 case control studies) with 135,871 women, who included 65,578 of wine and 70,293 of never drinkers. Results: In all studies, there was no significant difference in EOC risk between wine and never drinkers (odds ratio [OR], 1.13; 95% confidence interval [CI], 0.92 to 1.38; random effects). When we performed re-analysis according to the study design, 3 cohort and 7 case control studies showed that there were also no significant differences in EOC risk between wine and never drinkers, respectively (OR, 1.44 and 1.04; 95% CI, 0.74 and 2.82 and 0.88 to 1.22; random effects). In sub-analyses using 2 case-control studies, EOC risk was not different between former and never drinkers (OR, 1.12; 95% CI, 0.87 to 1.44; fixed effect), and between current and former drinkers (OR, 0.74; 95% CI, 0.41 to 1.34; random effects). Conclusion: Although resveratrol, abundantly found in wine, is a promising naturally occurring compound with chemopreventive properties on EOC in preclinical studies, this meta-analysis suggests the epidemiologic evidence shows no association between wine drinking and EOC risk.
DOI
10.3802/jgo.2010.21.2.112
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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