Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 신윤용 | - |
dc.date.accessioned | 2016-08-28T12:08:23Z | - |
dc.date.available | 2016-08-28T12:08:23Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1019-6439 | - |
dc.identifier.other | OAK-6670 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/220867 | - |
dc.description.abstract | In previous research, we focused on the discovery of K-ras biomarkers, and effects of genotoxic carcinogens on their expression were investigated in this study. It is well-known that mutated K-ras gene is involved in ∼30% of human cancers such as lung cancer. To search for K-ras oncogene-induced modulators in lung tissues of K-ras transgenic mice, we analyzed K-ras-specific genes and proteins related to cancer development, signal transduction, inflammation as well as tumor suppression in a previous study. In this study, we investigated the modulating effects of genotoxic carcinogen treatment on expression of K-ras-dependent modulated genes and proteins in lung tissues of K-ras Tg mice. In order to evaluate candidate K-ras markers modulated by genotoxic stress and to investigate whether a genotoxic carcinogen would enhance or inhibit carcinogenesis in lung tissues of the K-ras Tg mice, the anti-cancer drug melphalan was intraperitoneally injected into K-ras Tg mice every two days for four weeks. RT-qPCR and proteomics analyses were performed in order to confirm whether K-ras-specific biomarkers would be modulated by melphalan treatment in K-ras Tg mice. The decreased adenomas were histopathologically observed and K-ras expression was suppressed in melphalan-treated K-ras Tg mice. Melphalan also recovered the expression of K-ras-dependent modulated biomarkers. These results suggest that melphalan inhibits carcinogenesis via modulating K-ras-specific genes and proteins expressed in the lung tissues of K-ras Tg mice. | - |
dc.language | English | - |
dc.title | Melphalan inhibits adenoma development through modulating the expression of K-ras-specific markers in K-ras Tg mice | - |
dc.type | Article | - |
dc.relation.issue | 1 | - |
dc.relation.volume | 37 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 219 | - |
dc.relation.lastpage | 228 | - |
dc.relation.journaltitle | International Journal of Oncology | - |
dc.identifier.doi | 10.3892/ijo-00000670 | - |
dc.identifier.wosid | WOS:000279135000025 | - |
dc.identifier.scopusid | 2-s2.0-77953187372 | - |
dc.author.google | Lee S. | - |
dc.author.google | Choi H. | - |
dc.author.google | Kim E. | - |
dc.author.google | Kim H. | - |
dc.author.google | Park Y.-H. | - |
dc.author.google | Yu D.-Y. | - |
dc.author.google | Yoon S.-J. | - |
dc.author.google | Kim J. | - |
dc.author.google | Sheen Y. | - |
dc.author.google | Park S.-N. | - |
dc.author.google | Yoon D.-Y. | - |
dc.contributor.scopusid | 신윤용(6603872711) | - |
dc.date.modifydate | 20230411104830 | - |