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Antipsychotic effects of quetiapine in naturalistic long term follow up study

Title
Antipsychotic effects of quetiapine in naturalistic long term follow up study
Authors
Lee J.-S.Ahn J.H.Kim D.-H.Kim J.-J.Kim T.-Y.Yoo S.-Y.Lee D.-G.Lee S.-H.Lim S.-W.Lim W.-J.Jung I.-K.Jung H.-K.Cho D.-H.Cho I.-H.Kim C.-Y.
Ewha Authors
임원정
SCOPUS Author ID
임원정scopus
Issue Date
2010
Journal Title
Psychiatry Investigation
ISSN
1738-3684JCR Link
Citation
vol. 7, no. 2, pp. 128 - 134
Indexed
SCIE; SSCI; SCOPUS; KCI WOS scopus
Abstract
Objective: This study aimed to examine the effectiveness of quetiapine and the effects of dosage relates to its effectiveness on schizophrenia and schizoaffective disorder in a naturalistic setting in Korean people. Methods: This study was a 24-week, open-label, non-comparative, naturalistic study of quetiapine in patients diagnosed with schizophrenia and schizoaffective disorder according to DSM-IV. We stratified the patients into mild [(clinical global impression severity (CGI-S) <4 at baseline)] and severe groups (CGI-S ≥4 at baseline). We investigated the response rate, defined as clinical global impression improvement (CGI-I) ≤2, in the severe group and the aggravation rate in the mild group using the last-observation-carried-forward (LOCF) and the Kaplan-Meier method (K-M). Results: During the 24 weeks, 151 (18.4%) of the participants dropped out of the study. There was a significant decrease in the mean CGI-S score, from 4.5±1.1 at baseline to 2.8± 1.1 at 24 weeks. The response rate of severe group was 54.5% (estimated by LOCF) and 73.3% (K-M estimated) at 24 weeks. All patients who completed the study had taken a mean quetiapine dosage of 507.9±245.9 mg daily. The decrease of CGI-S score in high-dose group (the maximum dose was 750 mg/d or above) was statistically significant than that in recommended-dose group (the maximum dose was less than 750 mg/d). Conclusion: This study demonstrated the long-term effectiveness of quetiapine in the treatment of schizophrenia and schizoaffective disorder in a naturalistic setting in Korean people. This study suggests that higher than recommended quetiapine dosages could be more effective in some patients. Copyright © 2010 Korean Neuropsychiatric Association.
DOI
10.4306/pi.2010.7.2.128
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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