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dc.contributor.author정낙신-
dc.contributor.author최원준-
dc.date.accessioned2016-08-28T12:08:22Z-
dc.date.available2016-08-28T12:08:22Z-
dc.date.issued2010-
dc.identifier.issn0968-0896-
dc.identifier.otherOAK-6654-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/220856-
dc.description.abstractOn the basis of potent anti-hepatitis C virus (HCV) activity of 2′-C-hydroxymethyladenosine, 3′-C-substituted-methyl-ribofuranosyl pyrimidine and purine nucleosides were designed and synthesized from d-xylose. Among compounds tested, all adenine analogues, 4a, 4d, and 4g showed significant anti-HCV activity in a replicon-based cell assay irrespective of the substituent (Y = OH, N3, or F) at the 3′-C-substituted methyl position, among which 4g (Y = N3) was the most potent, but it is also cytotoxic. This study guarantees the 3′-C-substituted-methyl nucleoside serves as a new template for the development of new anti-HCV agents. © 2010 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.titleSynthesis and anti-hepatitis C virus (HCV) activity of 3′-C- substituted-methyl pyrimidine and purine nucleosides-
dc.typeArticle-
dc.relation.issue13-
dc.relation.volume18-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage4812-
dc.relation.lastpage4820-
dc.relation.journaltitleBioorganic and Medicinal Chemistry-
dc.identifier.doi10.1016/j.bmc.2010.05.002-
dc.identifier.wosidWOS:000279011000023-
dc.identifier.scopusid2-s2.0-77954214576-
dc.author.googleChoi W.J.-
dc.author.googleKim Y.M.-
dc.author.googleKim H.O.-
dc.author.googleLee H.W.-
dc.author.googleKim D.-E.-
dc.author.googlePark K.-S.-
dc.author.googleChong Y.-
dc.author.googleJeong L.S.-
dc.contributor.scopusid정낙신(16028528200)-
dc.contributor.scopusid최원준(55732412300;57211762651)-
dc.date.modifydate20230627112239-
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약학대학 > 약학과 > Journal papers
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