Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 정낙신 | - |
dc.contributor.author | 최원준 | - |
dc.date.accessioned | 2016-08-28T12:08:22Z | - |
dc.date.available | 2016-08-28T12:08:22Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0968-0896 | - |
dc.identifier.other | OAK-6654 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/220856 | - |
dc.description.abstract | On the basis of potent anti-hepatitis C virus (HCV) activity of 2′-C-hydroxymethyladenosine, 3′-C-substituted-methyl-ribofuranosyl pyrimidine and purine nucleosides were designed and synthesized from d-xylose. Among compounds tested, all adenine analogues, 4a, 4d, and 4g showed significant anti-HCV activity in a replicon-based cell assay irrespective of the substituent (Y = OH, N3, or F) at the 3′-C-substituted methyl position, among which 4g (Y = N3) was the most potent, but it is also cytotoxic. This study guarantees the 3′-C-substituted-methyl nucleoside serves as a new template for the development of new anti-HCV agents. © 2010 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.title | Synthesis and anti-hepatitis C virus (HCV) activity of 3′-C- substituted-methyl pyrimidine and purine nucleosides | - |
dc.type | Article | - |
dc.relation.issue | 13 | - |
dc.relation.volume | 18 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 4812 | - |
dc.relation.lastpage | 4820 | - |
dc.relation.journaltitle | Bioorganic and Medicinal Chemistry | - |
dc.identifier.doi | 10.1016/j.bmc.2010.05.002 | - |
dc.identifier.wosid | WOS:000279011000023 | - |
dc.identifier.scopusid | 2-s2.0-77954214576 | - |
dc.author.google | Choi W.J. | - |
dc.author.google | Kim Y.M. | - |
dc.author.google | Kim H.O. | - |
dc.author.google | Lee H.W. | - |
dc.author.google | Kim D.-E. | - |
dc.author.google | Park K.-S. | - |
dc.author.google | Chong Y. | - |
dc.author.google | Jeong L.S. | - |
dc.contributor.scopusid | 정낙신(16028528200) | - |
dc.contributor.scopusid | 최원준(55732412300;57211762651) | - |
dc.date.modifydate | 20230627112239 | - |