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Synthesis and anti-hepatitis C virus (HCV) activity of 3′-C- substituted-methyl pyrimidine and purine nucleosides
- Synthesis and anti-hepatitis C virus (HCV) activity of 3′-C- substituted-methyl pyrimidine and purine nucleosides
- Choi W.J.; Kim Y.M.; Kim H.O.; Lee H.W.; Kim D.-E.; Park K.-S.; Chong Y.; Jeong L.S.
- Ewha Authors
- 정낙신; 최원준
- Issue Date
- Journal Title
- Bioorganic and Medicinal Chemistry
- Bioorganic and Medicinal Chemistry vol. 18, no. 13, pp. 4812 - 4820
- SCI; SCIE; SCOPUS
- Document Type
- On the basis of potent anti-hepatitis C virus (HCV) activity of 2′-C-hydroxymethyladenosine, 3′-C-substituted-methyl-ribofuranosyl pyrimidine and purine nucleosides were designed and synthesized from d-xylose. Among compounds tested, all adenine analogues, 4a, 4d, and 4g showed significant anti-HCV activity in a replicon-based cell assay irrespective of the substituent (Y = OH, N3, or F) at the 3′-C-substituted methyl position, among which 4g (Y = N3) was the most potent, but it is also cytotoxic. This study guarantees the 3′-C-substituted-methyl nucleoside serves as a new template for the development of new anti-HCV agents. © 2010 Elsevier Ltd. All rights reserved.
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