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Synthesis and anti-hepatitis C virus (HCV) activity of 3′-C- substituted-methyl pyrimidine and purine nucleosides

Title
Synthesis and anti-hepatitis C virus (HCV) activity of 3′-C- substituted-methyl pyrimidine and purine nucleosides
Authors
Choi W.J.Kim Y.M.Kim H.O.Lee H.W.Kim D.-E.Park K.-S.Chong Y.Jeong L.S.
Ewha Authors
정낙신최원준
Issue Date
2010
Journal Title
Bioorganic and Medicinal Chemistry
ISSN
0968-0896JCR Link
Citation
vol. 18, no. 13, pp. 4812 - 4820
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
On the basis of potent anti-hepatitis C virus (HCV) activity of 2′-C-hydroxymethyladenosine, 3′-C-substituted-methyl-ribofuranosyl pyrimidine and purine nucleosides were designed and synthesized from d-xylose. Among compounds tested, all adenine analogues, 4a, 4d, and 4g showed significant anti-HCV activity in a replicon-based cell assay irrespective of the substituent (Y = OH, N3, or F) at the 3′-C-substituted methyl position, among which 4g (Y = N3) was the most potent, but it is also cytotoxic. This study guarantees the 3′-C-substituted-methyl nucleoside serves as a new template for the development of new anti-HCV agents. © 2010 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.bmc.2010.05.002
Appears in Collections:
약학대학 > 약학과 > Journal papers
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