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dc.contributor.author장준*
dc.date.accessioned2016-08-28T12:08:21Z-
dc.date.available2016-08-28T12:08:21Z-
dc.date.issued2010*
dc.identifier.issn0264-410X*
dc.identifier.otherOAK-6643*
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/220848-
dc.description.abstractRespiratory syncytial virus (RSV) is a major cause of severe lower respiratory tract disease in infancy and early childhood. Despite its importance as a pathogen, there is no licensed vaccine against RSV. The fusion (F) protein of RSV is a potentially important target for protective antiviral immune responses. Here, we studied the immune responses elicited by recombinant replication-deficient adenovirus (rAd)-based vaccines expressing the soluble F1 fragment of F protein (amino acids 155-524) in murine model. The expression of secreted F1 fragment by rAd was significantly increased by codon optimization. Strong mucosal IgA response was induced by single intranasal immunization of codon-optimized vaccine, rAd/F1co, but not by rAd/F1wt. A single intranasal immunization with rAd/F1co provided potent protection against subsequent RSV challenge. Interestingly, neither serum Ig nor T-cell response directed to F protein was detected in the rAd/F1co-immune mice, suggesting that protective immunity by rAd/F1co is mainly mediated through mucosal IgA induction. Indeed, co-delivery of cholera toxin B subunit significantly enhanced mucosal IgA responses by the optimized vaccine, which correlates with protective efficacy. Taken together, our data demonstrate that a single intranasal administration of rAd/F1co is sufficient for the protection and represents a promising prophylactic vaccination regimen against RSV infection. © 2010 Elsevier Ltd. All rights reserved.*
dc.languageEnglish*
dc.titleSingle mucosal immunization of recombinant adenovirus-based vaccine expressing F1 protein fragment induces protective mucosal immunity against respiratory syncytial virus infection*
dc.typeArticle*
dc.relation.issue22*
dc.relation.volume28*
dc.relation.indexSCI*
dc.relation.indexSCIE*
dc.relation.indexSCOPUS*
dc.relation.startpage3801*
dc.relation.lastpage3808*
dc.relation.journaltitleVaccine*
dc.identifier.doi10.1016/j.vaccine.2010.03.032*
dc.identifier.wosidWOS:000278877900009*
dc.identifier.scopusid2-s2.0-77952552645*
dc.author.googleKim S.*
dc.author.googleJang J.-E.*
dc.author.googleYu J.-R.*
dc.author.googleChang J.*
dc.contributor.scopusid장준(8735999100)*
dc.date.modifydate20231120165756*
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약학대학 > 약학과 > Journal papers
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