View : 20 Download: 0

Genomic analysis of the telomeric length effect on organismic lifespan in Caenorhabditis elegans

Title
Genomic analysis of the telomeric length effect on organismic lifespan in Caenorhabditis elegans
Authors
Park M.C.Park D.Lee E.-K.Park T.Lee J.
Ewha Authors
이은경
SCOPUS Author ID
이은경scopus
Issue Date
2010
Journal Title
Biochemical and Biophysical Research Communications
ISSN
0006-291XJCR Link
Citation
vol. 396, no. 2, pp. 382 - 387
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Telomeres are multifunctional elements that protect chromosomal ends. Telomere length affects lifespan and stress resistance. In our previous report, we found that the increase of telomere length extended organismic lifespan in Caenorhabditis elegans. To investigate the effect of the telomere length on organismic lifespan at the global gene expression level, we performed microarray experiments using mRNA from long telomere-containing worms. We identified genes that showed significant difference in transcript levels from long telomere-containing worms. We examined the expression patterns of these genes and measured lifespan of the worms over-expressing each of the up-regulated genes. Most up-regulated genes, when over-expressed, extended lifespan of C. elegans. In particular, over-expression of rnh-1.3 in the intestine extended lifespan in the daf-16-dependent manner and increased stress resistance. Interestingly, genes up-regulated in long telomeric worms partially overlapped with the genes whose transcription was increased by the rde-3 mutations, and the over-expression of each of these genes also extended the longevity of worms, raising the possibility that the telomere effect may involve molecular players shared with the RNAi machinery. © 2010 Elsevier Inc. All rights reserved.
DOI
10.1016/j.bbrc.2010.04.101
Appears in Collections:
자연과학대학 > 통계학전공 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE