DSpace at EWHA: A rapid synthesis of lavendustin-mimetic small molecules by click fragment assembly

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DC Field	Value	Language
dc.contributor.author	류재상	*
dc.date.accessioned	2016-08-28T12:08:19Z	-
dc.date.available	2016-08-28T12:08:19Z	-
dc.date.issued	2010	*
dc.identifier.issn	0960-894X	*
dc.identifier.other	OAK-6626	*
dc.identifier.uri	https://dspace.ewha.ac.kr/handle/2015.oak/220832	-
dc.description.abstract	Lavendustin-mimetic small molecules modifying the linker -CH 2-NH- with an 1,2,3-triazole ring have been synthesized via a click chemistry. Two pharmacophoric fragments of lavendustin were varied to investigate chemical space and the auxophoric -CH2-NH- was altered to an 1,2,3-triazole for rapid click conjugation. The small molecules were evaluated against HCT116 colon cancer and CCRF-CEM leukemia cell lines. Among 28 analogues, 3-phenylpropyl ester 26b inhibited CCRF-CEM leukemia cell growth with GI50 value of 0.9 μM. © 2010 Elsevier Ltd. All rights reserved.	*
dc.language	English	*
dc.title	A rapid synthesis of lavendustin-mimetic small molecules by click fragment assembly	*
dc.type	Article	*
dc.relation.issue	13	*
dc.relation.volume	20	*
dc.relation.index	SCI	*
dc.relation.index	SCIE	*
dc.relation.index	SCOPUS	*
dc.relation.startpage	3930	*
dc.relation.lastpage	3935	*
dc.relation.journaltitle	Bioorganic and Medicinal Chemistry Letters	*
dc.identifier.doi	10.1016/j.bmcl.2010.05.014	*
dc.identifier.wosid	WOS:000278644700021	*
dc.identifier.scopusid	2-s2.0-77954310547	*
dc.author.google	Yoon J.	*
dc.author.google	Ryu J.-S.	*
dc.contributor.scopusid	류재상(36081118200)	*
dc.date.modifydate	20231120165709	*