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Frequency of intrahepatic FoxP3+ regulatory T cells during the natural course of chronic hepatitis B: An immunohistochemical study using needle-biopsied liver tissue

Title
Frequency of intrahepatic FoxP3+ regulatory T cells during the natural course of chronic hepatitis B: An immunohistochemical study using needle-biopsied liver tissue
Authors
Bae J.Y.Kim H.K.Kang H.Cheong H.R.Song D.E.Sung S.H.Koo H.Han W.S.Lee J.K.Kim T.-H.Chung K.W.Cho M.-S.
Ewha Authors
한운섭구혜수성순희조민선이정경김태헌송동은
SCOPUS Author ID
한운섭scopusscopus; 구혜수scopus; 성순희scopus; 조민선scopus; 이정경scopus; 김태헌scopus
Issue Date
2010
Journal Title
Korean Journal of Pathology
ISSN
1738-1843JCR Link
Citation
vol. 44, no. 2, pp. 132 - 140
Indexed
SCOPUS WOS scopus
Abstract
Background: Regulatory T cells (Tregs) may contribute to the immunological hyporesponsiveness against hepatitis B virus (HBV), and this can result in chronic infection. Tregs suppress the T cell responses directed against HBV and they protect hepatocytes by down-regulating the immune responses that cause liver damage, but the role of Tregs has not been well characterized. Methods: Fifty four patients were selected and classified into three groups (12 were in the immune-tolerance phase, 35 were in the immune-clearance phase and 7 were in the asymptomatic virus carrier phase). We examined the frequency of CD3+, CD4+ & CD8+ T cells and forkhead box P3 (FoxP3)+ Tregs in the needle-biopsied liver tissue by performing immunohistochemistry. Results: The FoxP3+ Tregs were mainly located at the portal tracts. In the immune-clearance phase, the frequency of FoxP3+ Tregs was significantly increased compared to that of the immune-tolerance group and the asymptomatic carrier group. Increased FoxP3+ T cells were observed in the patients with a higher histologic inflammatory index. No correlation was observed among the numbers of FoxP3+ Tregs, the serum alanine aminotransferase level, detection of HBeAg and the HBV-DNA viral load. Conclusions: FoxP3+ Tregs may play important roles in suppressing the immune response to HBV and the complete elimination of HBV.
DOI
10.4132/KoreanJPathol.2010.44.2.132
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의학전문대학원 > 의학과 > Journal papers
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