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Polymerized urushiol of the commercially available rhus product in Korea

Title
Polymerized urushiol of the commercially available rhus product in Korea
Authors
Cheong S.H.Choi Y.W.Min B.S.Choi H.Y.
Ewha Authors
최혜영최유원
SCOPUS Author ID
최혜영scopus; 최유원scopus
Issue Date
2010
Journal Title
Annals of Dermatology
ISSN
1013-9087JCR Link
Citation
vol. 22, no. 1, pp. 16 - 20
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
Background: Systemic contact dermatitis commonly occurs with the intake of rhus (boiled chicken with rhus) as a health food and a folk medicine to cure gastrointestinal diseases in Korea. Rhus companies insist they have the technology for rhus detoxification. However, the numbers of systemic allergic contact dermatitis patients, caused by rhus, have not decreased. The principle of present techniques for rhus detoxification is the induction of the polymerization of urushiol, but polymerized urushiol may still have antigenicity, although to a diminished degree. The Korean Food and Drug Administration (KFDA) has a regulation to control urushiol use as a food. However, the laboratory method that KFDA uses for detection of rhus can only detect the urushiol monomer. Objective: We conducted experiments to detect polymerized urushiol in rhus products, which were considered not to include urushiol by the KFDA. Methods: Rhus product approved by the KFDA was separated with chloroform. The chloroform fractionation was accomplished on a recycle HPLC system. Four peaks were achieved and evaporated to give an amorphous powder. Each powder was analyzed on a NMR system and mass spectrometer. Results: The material considered to be urushiol dimer, with a 638 molecular weight (MW), was detected in one of the four powders as per the HPLC peaks. Conclusion: We concluded that commercially available rhus product is comprised of material considered to be urushiol dimer. Therefore, even if the antigenicity of the rhus products is low, this product may cause adverse effects and is not completely detoxified.
DOI
10.5021/ad.2010.22.1.16
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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