View : 284 Download: 0

Full metadata record

DC Field Value Language
dc.contributor.author권종범-
dc.contributor.author이한새-
dc.date.accessioned2017-08-28T20:36:43Z-
dc.date.available2017-08-28T20:36:43Z-
dc.date.issued2010-
dc.identifier.issn0261-4189-
dc.identifier.otherOAK-6481-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/220710-
dc.description.abstractAlthough recent studies highlight the importance of histone modifications and ATP-dependent chromatin remodelling in DNA double-strand break (DSB) repair, how these mechanisms cooperate has remained largely unexplored. Here, we show that the SWI/SNF chromatin remodelling complex, earlier known to facilitate the phosphorylation of histone H2AX at Ser-139 (S139ph) after DNA damage, binds to γ-H2AX (the phosphorylated form of H2AX)-containing nucleosomes in S139ph-dependent manner. Unexpectedly, BRG1, the catalytic subunit of SWI/SNF, binds to γ-H2AX nucleosomes by interacting with acetylated H3, not with S139ph itself, through its bromodomain. Blocking the BRG1 interaction with γ-H2AX nucleosomes either by deletion or overexpression of the BRG1 bromodomain leads to defect of S139ph and DSB repair. H3 acetylation is required for the binding of BRG1 to γ-H2AX nucleosomes. S139ph stimulates the H3 acetylation on γ-H2AX nucleosomes, and the histone acetyltransferase Gcn5 is responsible for this novel crosstalk. The H3 acetylation on γ-H2AX nucleosomes is induced by DNA damage. These results collectively suggest that SWI/SNF, γ-H2AX and H3 acetylation cooperatively act in a feedback activation loop to facilitate DSB repair. © 2010 European Molecular Biology Organization.-
dc.languageEnglish-
dc.titleA cooperative activation loop among SWI/SNF, γ-H2AX and H3 acetylation for DNA double-strand break repair-
dc.typeArticle-
dc.relation.issue8-
dc.relation.volume29-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage1434-
dc.relation.lastpage1445-
dc.relation.journaltitleEMBO Journal-
dc.identifier.doi10.1038/emboj.2010.27-
dc.identifier.wosidWOS:000276927000012-
dc.identifier.scopusid2-s2.0-77951498720-
dc.author.googleLee H.-S.-
dc.author.googlePark J.-H.-
dc.author.googleKim S.-J.-
dc.author.googleKwon S.-J.-
dc.author.googleKwon J.-
dc.contributor.scopusid권종범(7202469069)-
dc.date.modifydate20190901081003-
Appears in Collections:
자연과학대학 > 생명과학전공 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE