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dc.contributor.author곽혜선*
dc.date.accessioned2016-08-28T12:08:05Z-
dc.date.available2016-08-28T12:08:05Z-
dc.date.issued2010*
dc.identifier.issn1071-7544*
dc.identifier.otherOAK-6464*
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/220697-
dc.description.abstractThe objective of this study was to examine the absorption of alendronate from formulated transdermal delivery systems in rats and humans. When alendronate was applied to rats by transdermal delivery systems (7.2mg) and oral administration (30mg/kg), a statistically significant difference was found in the amount remaining to be excreted at time t (Ae(t)) and the amount remaining to be excreted at time 0 (Ae∞) (p<0.01). The highest Ae ∞ (1267.7±65.2 ng) was found in the formulation containing 6% caprylic acid in propylene glycol (PG), which was 5.4- and 2.0-times higher than the PG only formulation and oral administration, respectively. Compared to oral administration, significantly delayed half-life values were obtained from all the formulated transdermal delivery systems. There was a linear relationship (r20.9854) between the drug loading dose and Ae∞. The Ae∞ values from the transdermal delivery system containing 6% caprylic acid (53.8mg as alendronate) and an oral product (Fosamax®, 70mg as alendronate) in humans were 127.0±34.2 g and 237.2±56.3 g, respectively. The dose-adjusted relative Ae ∞ ratio of the transdermal delivery system to oral product was calculated to be 69.7%. The long half-life of alendronate in the transdermal delivery system (50.6±6.4h), compared to that of the oral product (3.5±1.1h) could allow less-frequent dosing. In conclusion, this study showed that a transdermal delivery system containing 6% caprylic acid in PG could be a favorable alternative for alendronate administration. © 2010 Informa UK Ltd.*
dc.languageEnglish*
dc.titlePharmacokinetic characteristics of formulated alendronate transdermal delivery systems in rats and humans*
dc.typeArticle*
dc.relation.issue4*
dc.relation.volume17*
dc.relation.indexSCIE*
dc.relation.indexSCOPUS*
dc.relation.startpage249*
dc.relation.lastpage254*
dc.relation.journaltitleDrug Delivery*
dc.identifier.doi10.3109/10717541003680999*
dc.identifier.wosidWOS:000276766200007*
dc.identifier.scopusid2-s2.0-77951445382*
dc.author.googleChoi A.*
dc.author.googleGang H.*
dc.author.googleWhang J.*
dc.author.googleGwak H.*
dc.date.modifydate20240123100124*
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약학대학 > 약학과 > Journal papers
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