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Clinical and radiographic features of adult-onset ankylosing spondylitis in Korean patients: Comparisons between males and females

Title
Clinical and radiographic features of adult-onset ankylosing spondylitis in Korean patients: Comparisons between males and females
Authors
Jung Y.-O.Kim I.Kim S.Suh C.-H.Park H.J.Park W.Kwon S.R.Jeong J.C.Lee Y.J.Ryu H.J.Park Y.B.Lee J.Lee Y.-H.Seo Y.Chung W.T.Hong S.-J.Hong Y.-S.Baek H.J.Choi H.J.Kang H.-J.Lee C.-H.Kim S.-H.Kim H.A.
Ewha Authors
이지수
SCOPUS Author ID
이지수scopus
Issue Date
2010
Journal Title
Journal of Korean Medical Science
ISSN
1011-8934JCR Link
Citation
vol. 25, no. 4, pp. 532 - 535
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Abstract
The objective of this study was to investigate clinical and radiographic features and gender differences in Korean patients with adult-onset ankylosing spondylitis. Multicenter cross-sectional studies were conducted in the rheumatology clinics of 13 Korean tertiary referral hospitals. All patients had a confirmed diagnosis of ankylosing spondylitis according to the modified New York criteria. Clinical, laboratory, and radio-graphic features were evaluated and disease activities were assessed using the Bath ankylosing spondylitis disease activity index. Five hundred and five patients were recruited. The male to female ratio was 6.1:1. Average age at symptom onset was 25.4±8.9 yr and average disease duration was 9.6±6.8 yr. Males manifested symptoms at a significantly earlier age. HLA-B27 was more frequently positive in males. Hips were more commonly affected in males, and knees in females. When spinal mobility was measured using tragus-to-wall distance and the modified Schober's test, females had significantly better results. Radiographic spinal changes, including bamboo spine and syndesmophytes, were more common in males after adjustment of confounding factors. In conclusion, we observed significant gender differences in radiographic spinal involvement as well as other clinical manifestations among Korea patients with adult-onset ankylosing spondylitis. These findings may influence the timing of the diagnosis and the choice of treatment. © 2010 The Korean Academy of Medical Sciences.
DOI
10.3346/jkms.2010.25.4.532
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의학전문대학원 > 의학과 > Journal papers
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