View : 19 Download: 0

Oriental medicine Jangwonhwan reduces Aβ(1-42) level and β-amyloid deposition in the brain of Tg-APPswe/PS1dE9 mouse model of Alzheimer disease

Title
Oriental medicine Jangwonhwan reduces Aβ(1-42) level and β-amyloid deposition in the brain of Tg-APPswe/PS1dE9 mouse model of Alzheimer disease
Authors
Seo J.-S.Yun J.-H.Baek I.-S.Leem Y.-H.Kang H.-W.Cho H.K.Lyu Y.-S.Son H.-J.Han P.-L.
Ewha Authors
한평림손형진
SCOPUS Author ID
한평림scopus; 손형진scopus
Issue Date
2010
Journal Title
Journal of Ethnopharmacology
ISSN
0378-8741JCR Link
Citation
vol. 128, no. 1, pp. 206 - 212
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Ethnopharmacological relevance: Jangwonhwan, a boiled extract of 12 medicinal plants/mushroom including Korean red ginseng (Panax ginseng C.A. Meyer), has been prescribed for patients with cognitive dysfunction and are believed to induce brain activity enhancement, provide light sedation, and facilitate sound sleep. Aim of the study: The present study was carried out to investigate whether Jangwonhwan has a beneficial effect on the brain of Alzheimer disease. Materials and methods: The transgenic mice of Alzheimer disease, Tg-APPswe/PS1dE9, were fed a modified recipe of Jangwonhwan consisting of a boiled extract of 7 herbs/mushroom (called LMK02-Jangwonhwan) at 400 mg/kg/day of dose for 3 months from 4.5 months of age. Immunohistological and ELISA analyses were used to assess the Aβ accumulation and plaque deposition in the brain. Other in vitro and in vivo works were performed to understand the underlying mechanism. Results: LMK02-Jangwonhwan notably reduced Aβ(1-42) and Aβ(1-40) levels, concomitantly with a reduction of plaque deposition, in the brain of Tg-APPswe/PS1dE9 mice. LMK02-Jangwonhwan partially suppressed oxidative stress accumulation, and prevented the down-regulation of phospho-CREB and calbindin typically seen in the hippocampus of AD-like brains. In vitro study with SH-SY5Y neuroblastoma cells showed that LMK02-Jangwonhwan inhibited oxidative stress and Aβ-induced neurotoxicity. Conclusion: The present study suggests that LMK02-Jangwonhwan confers a therapeutic potential to ameliorate AD-like pathology in the brain of Tg-APPswe/PS1dE9 mice. © 2010 Elsevier Ireland Ltd.
DOI
10.1016/j.jep.2010.01.014
Appears in Collections:
일반대학원 > 뇌·인지과학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE