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New assessment of the N1-N2 substaging in stage III colorectal cancer

Title
New assessment of the N1-N2 substaging in stage III colorectal cancer
Authors
Cho S.W.Jeong G.Y.Lee R.-A.Kim K.H.Chung S.S.
Ewha Authors
김광호이령아정순섭
SCOPUS Author ID
김광호scopus; 이령아scopus; 정순섭scopus
Issue Date
2010
Journal Title
Journal of the Korean Surgical Society
ISSN
1226-0053JCR Link
Citation
vol. 78, no. 3, pp. 171 - 176
Indexed
SCOPUS WOS scopus
Abstract
Purpose: The five-year survival rates of patients with stage III colorectal cancer have been reported widely ranging from 22 to 69 percent. Hence, reliable substaging is important for the management of stage III colorectal cancer patients. Therefore, we tried to assess the substages and investigate the possibility of other discriminating numbers for nodal substaging. Methods: The 381 patients with node-positive colorectal cancer who had undergone surgery, were retrospectively categorized by the number of positive nodes. The patients were grouped in five ways, and each grouping was divided into two subgroups according to the number of positive nodes. The subgroups of each grouping were as follows; in LN1 group, N1=1, N2>1; in LN2 group, N1=2, N2>2; in LN3 group, N1=3, N2>3; in LN4 group, N1=4, N2>4; in LN5 group, N1=5, N2>5. We compared the survival rate of each groups. Results: Node-positive patients had a five-year survival rate of 55.2 percent. The statistical differences between the N1 and N2 subgroups of each grouping were as follows: LN1 group (P=0.0128), LN2 group (P=0.0052), LN3 group (P=0.6268), LN4 group (P=0.1480), and LN5 group (P=0.6875). Conclusion: There were significant differences in the five-year survival rates between N1 and N2 in the LN1 group and LN2 group, but there were no differences between N1 and N2 in the other groupings. These data raise the possibility that a novel N1~N2 substaging (N1: 1∼2; N2: >2) is superior to the current N1∼N2 substaging (N1: 1∼3; N2: >3).
DOI
10.4174/jkss.2010.78.3.171
Appears in Collections:
의과대학 > 의학과 > Journal papers
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