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Placental gene expression is related to glucose metabolism and fetal cord blood levels of insulin and insulin-like growth factors in intrauterine growth restriction

Title
Placental gene expression is related to glucose metabolism and fetal cord blood levels of insulin and insulin-like growth factors in intrauterine growth restriction
Authors
Lee M.H.Jeon Y.J.Lee S.M.Park M.H.Jung S.-C.Kim Y.J.
Ewha Authors
김영주박미혜정성철
SCOPUS Author ID
김영주scopus; 박미혜scopus; 정성철scopus
Issue Date
2010
Journal Title
Early Human Development
ISSN
0378-3782JCR Link
Citation
Early Human Development vol. 86, no. 1, pp. 45 - 50
Indexed
SCI; SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Despite the importance of glucose for fetal growth, placental gene expression related to the glycolytic pathway has not been studied. Insulin-like growth factors (IGFs) and insulin are known to play a critical role in fetal growth. In our study, we identified differentially expressed genes related to the glycolytic pathway using oligonucleotide microarray analysis and confirmed these genes with quantitative real-time PCR between uncomplicated pregnancies and pregnancies with intrauterine growth restriction (IUGR). We also compared the concentrations of insulin and IGFs in cord blood between the two groups. Microarray experiments identified increased expression of glycolytic enzyme-related genes, including lactate dehydrogenase C (LDHC), dihydrolipoamide S-acetyltransferase (DLAT), 6 phosphofructo-2-kinase/fructose-2, 6-biphosphatase 2 (PFKFB2), oxoglutarate dehydrogenase, phosphorylase, and insulin-like growth factor (IGF)-II and decreased expression of IGF-I in placentas from pregnancies with IUGR (p<0.05). There were significantly lower concentrations of glucose, insulin, IGF-1, and IGF-II in the fetal cord blood of pregnancies with IUGR (p<0.05). Microarray analysis revealed increased expression of enzyme genes related to the tricarboxylic acid cycle pathway in placentas from pregnancies with IUGR; the cause of hypoglycaemia in IUGR is attributed to increased glycolytic pathway activity in placentas from pregnancies with IUGR. © 2010 Elsevier Ltd.
DOI
10.1016/j.earlhumdev.2010.01.001
Appears in Collections:
의과대학 > 의학과 > Journal papers
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