Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 권영주 | * |
dc.date.accessioned | 2016-08-28T12:08:56Z | - |
dc.date.available | 2016-08-28T12:08:56Z | - |
dc.date.issued | 2010 | * |
dc.identifier.issn | 0968-0896 | * |
dc.identifier.other | OAK-6365 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/220613 | - |
dc.description.abstract | A series of 2-(thienyl-2-yl or -3-yl)-4-furyl-6-aryl pyridine derivatives were designed, synthesized, and evaluated for their topoisomerase I and II inhibition and cytotoxic activity against several human cancer cell lines. Compounds 10-19 showed moderate topoisomerase I and II inhibitory activity and 20-29 showed significant topoisomerase II inhibitory activity. Structure-activity relationship study revealed that 4-(5-chlorofuran-2-yl)-2-(thiophen-3-yl) moiety has an important role in displaying topoisomerase II inhibition. © 2010 Elsevier Ltd. All rights reserved. | * |
dc.language | English | * |
dc.title | Synthesis of 2-(thienyl-2-yl or -3-yl)-4-furyl-6-aryl pyridine derivatives and evaluation of their topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship | * |
dc.type | Article | * |
dc.relation.issue | 6 | * |
dc.relation.volume | 18 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 2245 | * |
dc.relation.lastpage | 2254 | * |
dc.relation.journaltitle | Bioorganic and Medicinal Chemistry | * |
dc.identifier.doi | 10.1016/j.bmc.2010.01.065 | * |
dc.identifier.wosid | WOS:000275513700021 | * |
dc.identifier.scopusid | 2-s2.0-77649237047 | * |
dc.author.google | Thapa P. | * |
dc.author.google | Karki R. | * |
dc.author.google | Choi H. | * |
dc.author.google | Choi J.H. | * |
dc.author.google | Yun M. | * |
dc.author.google | Jeong B.-S. | * |
dc.author.google | Jung M.-J. | * |
dc.author.google | Nam J.M. | * |
dc.author.google | Na Y. | * |
dc.author.google | Cho W.-J. | * |
dc.author.google | Kwon Y. | * |
dc.author.google | Lee E.-S. | * |
dc.contributor.scopusid | 권영주(12446435600) | * |
dc.date.modifydate | 20240123101932 | * |