View : 491 Download: 0

Full metadata record

DC Field Value Language
dc.contributor.author권영주*
dc.date.accessioned2016-08-28T12:08:56Z-
dc.date.available2016-08-28T12:08:56Z-
dc.date.issued2010*
dc.identifier.issn0968-0896*
dc.identifier.otherOAK-6365*
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/220613-
dc.description.abstractA series of 2-(thienyl-2-yl or -3-yl)-4-furyl-6-aryl pyridine derivatives were designed, synthesized, and evaluated for their topoisomerase I and II inhibition and cytotoxic activity against several human cancer cell lines. Compounds 10-19 showed moderate topoisomerase I and II inhibitory activity and 20-29 showed significant topoisomerase II inhibitory activity. Structure-activity relationship study revealed that 4-(5-chlorofuran-2-yl)-2-(thiophen-3-yl) moiety has an important role in displaying topoisomerase II inhibition. © 2010 Elsevier Ltd. All rights reserved.*
dc.languageEnglish*
dc.titleSynthesis of 2-(thienyl-2-yl or -3-yl)-4-furyl-6-aryl pyridine derivatives and evaluation of their topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship*
dc.typeArticle*
dc.relation.issue6*
dc.relation.volume18*
dc.relation.indexSCI*
dc.relation.indexSCIE*
dc.relation.indexSCOPUS*
dc.relation.startpage2245*
dc.relation.lastpage2254*
dc.relation.journaltitleBioorganic and Medicinal Chemistry*
dc.identifier.doi10.1016/j.bmc.2010.01.065*
dc.identifier.wosidWOS:000275513700021*
dc.identifier.scopusid2-s2.0-77649237047*
dc.author.googleThapa P.*
dc.author.googleKarki R.*
dc.author.googleChoi H.*
dc.author.googleChoi J.H.*
dc.author.googleYun M.*
dc.author.googleJeong B.-S.*
dc.author.googleJung M.-J.*
dc.author.googleNam J.M.*
dc.author.googleNa Y.*
dc.author.googleCho W.-J.*
dc.author.googleKwon Y.*
dc.author.googleLee E.-S.*
dc.contributor.scopusid권영주(12446435600)*
dc.date.modifydate20240123101932*
Appears in Collections:
약학대학 > 약학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

BROWSE