View : 52 Download: 12

Over-expression of thymosin β4 promotes abnormal tooth development and stimulation of hair growth

Title
Over-expression of thymosin β4 promotes abnormal tooth development and stimulation of hair growth
Authors
Cha H.-J.Philp D.Lee S.-H.Moon H.-S.Kleinman H.K.Nakamura T.
Ewha Authors
문혜성
SCOPUS Author ID
문혜성scopus
Issue Date
2010
Journal Title
International Journal of Developmental Biology
ISSN
0214-6282JCR Link
Citation
vol. 54, no. 1, pp. 135 - 140
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Thymosin β4 has multi-functional roles in cell physiology. It accelerates wound healing, hair growth and angiogenesis, and increases laminin-5 expression in corneal epithelium. Furthermore, thymosin β4 stimulates tumor growth and metastasis by induction of cell migration and vascular endothelial growth factor-mediated angiogenesis. Using a construct on the skinspecific keratin-5 promoter, we have developed thymosin β4 over-expressing transgenic mice to further study its functional roles. Thymosin β4 in adult skin and in embryonic stages of the transgenic mouse was analyzed by both Western blot and immunohistochemistry. The overexpression of thymosin β4 was observed especially around hair follicles and in the teeth in the transgenic mice. We examined the phenotype of the thymosin β4 over-expressing mice. Hair growth was accelerated. In addition, the transgenic mice had abnormally-shaped white teeth and dull incisors. We found that the expression of laminin-5 was up-regulated in the skin of the transgenic mice. We conclude that thymosin β4 has an important physiological role in hair growth and in tooth development. © 2009 UBC Press.
DOI
10.1387/ijdb.082735hc
Appears in Collections:
의과대학 > 의학과 > Journal papers
Files in This Item:
Over-expression of thymosin β4 promotes abnormal tooth development and stimulation of hair growth.pdf(4.58 MB)Download
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE