DSpace at EWHA: Design, synthesis, and biological evaluation of 3,4,5-trimethoxyphenyl acrylamides as antinarcotic agents

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DC Field	Value	Language
dc.contributor.author	오세관	*
dc.contributor.author	정재철	*
dc.date.accessioned	2016-08-28T12:08:54Z	-
dc.date.available	2016-08-28T12:08:54Z	-
dc.date.issued	2010	*
dc.identifier.issn	1475-6366	*
dc.identifier.other	OAK-6327	*
dc.identifier.uri	https://dspace.ewha.ac.kr/handle/2015.oak/220581	-
dc.description.abstract	The synthesis and biological evaluation of 3,4,5-trimethoxyphenyl acrylamides 1af as novel antinarcotic agents are described. The molecules were prepared by the Wittig reaction, followed by a coupling reaction between 3,4,5-trimethoxycinnamic acid (9) and aliphatic amines, which resulted in good yields. When tested for biological activity, compounds 1df exhibited strong inhibitory effects on the morphine withdrawal syndrome in mice due to their high binding affinities with serotonergic 5-HT1A receptors. © 2010 Informa UK Ltd.	*
dc.language	English	*
dc.title	Design, synthesis, and biological evaluation of 3,4,5-trimethoxyphenyl acrylamides as antinarcotic agents	*
dc.type	Article	*
dc.relation.issue	1	*
dc.relation.volume	25	*
dc.relation.index	SCI	*
dc.relation.index	SCIE	*
dc.relation.index	SCOPUS	*
dc.relation.startpage	38	*
dc.relation.lastpage	43	*
dc.relation.journaltitle	Journal of Enzyme Inhibition and Medicinal Chemistry	*
dc.identifier.doi	10.3109/14756360902932784	*
dc.identifier.wosid	WOS:000275000900005	*
dc.identifier.scopusid	2-s2.0-74349101993	*
dc.author.google	Jung J.-C.	*
dc.author.google	Min D.	*
dc.author.google	Kim H.	*
dc.author.google	Jang S.	*
dc.author.google	Lee Y.	*
dc.author.google	Park W.	*
dc.author.google	Khan I.A.	*
dc.author.google	Moon H.-I.	*
dc.author.google	Jung M.	*
dc.author.google	Oh S.	*
dc.contributor.scopusid	오세관(7404103757)	*
dc.contributor.scopusid	정재철(7402897187)	*
dc.date.modifydate	20240123112233	*