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Design, synthesis, and biological evaluation of 3,4,5-trimethoxyphenyl acrylamides as antinarcotic agents

Title
Design, synthesis, and biological evaluation of 3,4,5-trimethoxyphenyl acrylamides as antinarcotic agents
Authors
Jung J.-C.Min D.Kim H.Jang S.Lee Y.Park W.Khan I.A.Moon H.-I.Jung M.Oh S.
Ewha Authors
오세관정재철
SCOPUS Author ID
오세관scopus
Issue Date
2010
Journal Title
Journal of Enzyme Inhibition and Medicinal Chemistry
ISSN
1475-6366JCR Link
Citation
vol. 25, no. 1, pp. 38 - 43
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The synthesis and biological evaluation of 3,4,5-trimethoxyphenyl acrylamides 1af as novel antinarcotic agents are described. The molecules were prepared by the Wittig reaction, followed by a coupling reaction between 3,4,5-trimethoxycinnamic acid (9) and aliphatic amines, which resulted in good yields. When tested for biological activity, compounds 1df exhibited strong inhibitory effects on the morphine withdrawal syndrome in mice due to their high binding affinities with serotonergic 5-HT1A receptors. © 2010 Informa UK Ltd.
DOI
10.3109/14756360902932784
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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