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Innate immunity and gut-microbe mutualism in Drosophila

Title
Innate immunity and gut-microbe mutualism in Drosophila
Authors
Ryu J.-H.Ha E.-M.Lee W.-J.
Ewha Authors
이원재
Issue Date
2010
Journal Title
Developmental and Comparative Immunology
ISSN
0145-305XJCR Link
Citation
vol. 34, no. 4, pp. 369 - 376
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Metazoan guts face a wide variety of microorganisms upon exposure to the environment, including beneficial symbionts, non-symbionts, food-borne microbes and life-threatening pathogens. Recent evidence has shown that the innate immunity of gut epithelia, such as anti-microbial peptide- and reactive oxygen species-based immune systems, actively participate in gut-microbe homeostasis by shaping the commensal community while efficiently eliminating unwanted bacteria. Therefore, elucidation of the regulatory mechanism by which gut innate immunity occurs at the molecular level will provide a novel perspective of gut-microbe mutualisms as well as of gut diseases caused by alterations in the innate immunity. © 2009 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.dci.2009.11.010
Appears in Collections:
일반대학원 > 바이오융합과학과 > Journal papers
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