Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 현동훈 | * |
dc.date.accessioned | 2016-08-28T12:08:51Z | - |
dc.date.available | 2016-08-28T12:08:51Z | - |
dc.date.issued | 2010 | * |
dc.identifier.issn | 0304-3940 | * |
dc.identifier.other | OAK-6302 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/220558 | - |
dc.description.abstract | The objective of the present study was to examine the role of selenium in the metabolism of Aβ and in Aβ-induced neuronal death. Selenium treatment significantly reduced Aβ40, Aβ42, and sAPPβ production by reducing Aβ producing β-secretase and γ-secretase activities. The lipid peroxidation product 4-Hydroxynonenal (HNE)-induced transcription of β-secretase (BACE1) was blocked by selenium. Finally, our data show that selenium protects against HNE and Aβ-mediated toxicity in primary cultured neurons. The present study suggests that selenium may be able to salvage the neuronal degeneration of Alzheimer's disease, thereby limiting β-amyloid production and neuronal death. © 2009 Elsevier Ireland Ltd. All rights reserved. | * |
dc.language | English | * |
dc.title | Selenium attenuates Aβ production and Aβ-induced neuronal death | * |
dc.type | Article | * |
dc.relation.issue | 3 | * |
dc.relation.volume | 469 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 391 | * |
dc.relation.lastpage | 395 | * |
dc.relation.journaltitle | Neuroscience Letters | * |
dc.identifier.doi | 10.1016/j.neulet.2009.12.035 | * |
dc.identifier.wosid | WOS:000274722100023 | * |
dc.identifier.scopusid | 2-s2.0-73649138850 | * |
dc.author.google | Gwon A.-R. | * |
dc.author.google | Park J.-S. | * |
dc.author.google | Park J.-H. | * |
dc.author.google | Baik S.-H. | * |
dc.author.google | Jeong H.-Y. | * |
dc.author.google | Hyun D.-H. | * |
dc.author.google | Park K.W. | * |
dc.author.google | Jo D.-G. | * |
dc.contributor.scopusid | 현동훈(7005049041) | * |
dc.date.modifydate | 20240123112641 | * |