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Selenium attenuates Aβ production and Aβ-induced neuronal death

Title
Selenium attenuates Aβ production and Aβ-induced neuronal death
Authors
Gwon A.-R.Park J.-S.Park J.-H.Baik S.-H.Jeong H.-Y.Hyun D.-H.Park K.W.Jo D.-G.
Ewha Authors
현동훈
SCOPUS Author ID
현동훈scopus
Issue Date
2010
Journal Title
Neuroscience Letters
ISSN
0304-3940JCR Link
Citation
vol. 469, no. 3, pp. 391 - 395
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The objective of the present study was to examine the role of selenium in the metabolism of Aβ and in Aβ-induced neuronal death. Selenium treatment significantly reduced Aβ40, Aβ42, and sAPPβ production by reducing Aβ producing β-secretase and γ-secretase activities. The lipid peroxidation product 4-Hydroxynonenal (HNE)-induced transcription of β-secretase (BACE1) was blocked by selenium. Finally, our data show that selenium protects against HNE and Aβ-mediated toxicity in primary cultured neurons. The present study suggests that selenium may be able to salvage the neuronal degeneration of Alzheimer's disease, thereby limiting β-amyloid production and neuronal death. © 2009 Elsevier Ireland Ltd. All rights reserved.
DOI
10.1016/j.neulet.2009.12.035
Appears in Collections:
자연과학대학 > 생명과학전공 > Journal papers
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