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When is electrical cortical stimulation more likely to produce afterdischarges?

Title
When is electrical cortical stimulation more likely to produce afterdischarges?
Authors
Lee H.W.Webber W.R.S.Crone N.Miglioretti D.L.Lesser R.P.
Ewha Authors
이향운
SCOPUS Author ID
이향운scopus
Issue Date
2010
Journal Title
Clinical Neurophysiology
ISSN
1388-2457JCR Link
Citation
vol. 121, no. 1, pp. 14 - 20
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Objective: To study when afterdischarges (ADs) are more likely to occur during cortical stimulation. Methods: We examined 6250 electrical stimulation trials in 13 patients with subdural electrodes, studying whether AD occurrence during a trial was influenced by electrode pair stimulated or AD occurrence during the previous trial. In total 545 electrodes were stimulated, 119 frontal (pre-perirolandic), 289 perirolandic, 36 parietal (post-perirolandic), 95 temporal, and 6 occipital. Results: When the same electrode pair was stimulated as the prior trial, 19% produced ADs compared to 5% of trials when a different electrodes pair was stimulated (p < 0.0001). When trials showed ADs, and the next trial stimulated the same electrode pair, ADs occurred in 46% of cases, compared to 13% of trials following trials without ADs (p < 0.0001). AD probability decreased with increased inter-trial interval length only when the prior trial was at the same electrode pair and had produced an AD (p = 0.001). AD probability increased with stimulation duration, whether the trial followed a trial with (p < 0.001) or without (p < 0.0001) an AD. Conclusions: ADs were more likely to occur when an electrode pair showed ADs and was stimulated again, especially when stimulating after short inter-trial intervals or for longer duration. Significance: When ADs occur, waiting about a minute before resuming stimulation might lessen the likelihood of AD recurrence. © 2009 International Federation of Clinical Neurophysiology.
DOI
10.1016/j.clinph.2009.10.001
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의학전문대학원 > 의학과 > Journal papers
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