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Uterine artery notch is associated with increased placental endothelial nitric oxide synthase and heat shock protein

Title
Uterine artery notch is associated with increased placental endothelial nitric oxide synthase and heat shock protein
Authors
Kim Y.J.Lee B.E.Lee H.Y.Park H.S.Ha E.H.Jung S.C.Pang M.G.
Ewha Authors
하은희김영주박혜숙이화영정성철
SCOPUS Author ID
하은희scopus; 김영주scopus; 박혜숙scopus; 이화영scopus; 정성철scopus
Issue Date
2010
Journal Title
Journal of Maternal-Fetal and Neonatal Medicine
ISSN
1476-7058JCR Link
Citation
vol. 23, no. 2, pp. 153 - 157
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Objective.This study was undertaken to evaluate whether uterine artery notch is associated with placental expression of endothelial nitric oxide synthase (eNOS), Heat shock protein 70 (Hsp70), and Lectin-like oxidized low-density lipoprotein receptor (Lox) in pregnant women. Study design.Uterine artery Doppler was performed in 30 pregnant women divided into two groups with or without the presence of uterine artery notches. After delivery, placental expression of eNOS, Hsp70, and Lox were evaluated with western blot analysis. Results.Higher levels of placental eNOS (p=0.02) and Hsp70 (p=0.001) were expressed in the group with uterine artery notch compared with the group without uterine artery notch. There was no significant difference for placental Lox expression between group with uterine artery notch and without uterine artery notch (p=0.17). Conclusion.Our results suggest that uterine artery notch is associated with increased placental expression of eNOS and Hsp in pregnant women. © 2009 Informa UK Ltd.
DOI
10.3109/14767050903156676
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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