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Chitosan-coated poly(vinyl alcohol) nanofibers for wound dressings

Title
Chitosan-coated poly(vinyl alcohol) nanofibers for wound dressings
Authors
Kang Y.O.Yoon I.-S.Lee S.Y.Kim D.-D.Lee S.J.Park W.H.Hudson S.M.
Ewha Authors
이승진
SCOPUS Author ID
이승진scopus
Issue Date
2010
Journal Title
Journal of Biomedical Materials Research - Part B Applied Biomaterials
ISSN
1552-4973JCR Link
Citation
vol. 92, no. 2, pp. 568 - 576
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
A PVA nanofibrous matrix was prepared by electrospinning an aqueous 10 wt % PVA solution. The mean diameter of the PVA nanofibers electrospun from the PVA aqueous solution was 240 nm. The water resistance of the as-spun PVA nanofibrous matrix was improved by physically crosslinking the PVA nanofibers by heat treatment at 150°C for 10 min, which were found to be the optimal heat treatment conditions determined from chemical and morphological considerations. In addition, the heat-treated PVA (H-PVA) nanofibrous matrix was coated with a chitosan solution to construct biomimetic nanofibrous wound dressings. The chitosan-coated PVA (C-PVA) nanofibrous matrix showed less hydrophilic and better tensile properties than the H-PVA nanofibrous matrix. The effect of the chitosan coating on open wound healing in a mouse was examined. The C-PVA and H-PVA nanofibrous matrices showed faster wound healing than the control. The histological examination and mechanical stability revealed the C-PVA nanofibrous matrix to be more effective as a wound-healing accelerator in the early stages of wound healing than the H-PVA nanofibrous matrix. © 2009 Wiley Periodicals, Inc.
DOI
10.1002/jbm.b.31554
Appears in Collections:
약학대학 > 약학과 > Journal papers
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