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dc.contributor.author최병옥-
dc.contributor.author조인호-
dc.date.accessioned2016-08-28T12:08:47Z-
dc.date.available2016-08-28T12:08:47Z-
dc.date.issued2010-
dc.identifier.issn0969-9961-
dc.identifier.otherOAK-6257-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/220518-
dc.description.abstractNeuromyelitis optica (NMO) is a severe idiopathic inflammatory disease of the central nervous system primarily affecting the optic nerves and spinal cord. In this study, we generated genome-wide SNP data from NMO patients and normal controls (53 cases and 240 controls), and followed up on the association signals with samples from a larger number of inflammatory demyelinating diseases, including NMO (n = 93), multiple sclerosis (MS, n = 71), idiopathic recurrent transverse myelitis (IRTM, n = 57), and normal controls (n = 240). Statistical analyses revealed that a common promoter SNP in CYP7A1 has a protective/gene dose-dependent effect on the risk of NMO (P = 0.0004). A stronger association between the variables and subsequently, a higher protective effect (lower OR) on the risk of NMO were observed among patients carrying the "G/G" genotype of rs3808607 than those with the "T/G" genotype (OR = 0.38/P = 0.01 vs. OR = 0.12/P = 0.0004, respectively). The associations which were only observed in patients with NMO suggest that there are differences in the genetic etiology of the inflammatory demyelinating diseases (NMO, classical MS, and IRTM). © 2009 Elsevier Inc. All rights reserved.-
dc.languageEnglish-
dc.titleCommon CYP7A1 promoter polymorphism associated with risk of neuromyelitis optica-
dc.typeArticle-
dc.relation.issue2-
dc.relation.volume37-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage349-
dc.relation.lastpage355-
dc.relation.journaltitleNeurobiology of Disease-
dc.identifier.doi10.1016/j.nbd.2009.10.013-
dc.identifier.wosidWOS:000274224400014-
dc.identifier.scopusid2-s2.0-73049089684-
dc.author.googleKim H.J.-
dc.author.googlePark H.-Y.-
dc.author.googleKim E.-
dc.author.googleLee K.-S.-
dc.author.googleKim K.-K.-
dc.author.googleChoi B.-O.-
dc.author.googleKim S.M.-
dc.author.googleBae J.S.-
dc.author.googleLee S.O.-
dc.author.googleChun J.Y.-
dc.author.googlePark T.J.-
dc.author.googleCheong H.S.-
dc.author.googleJo I.-
dc.author.googleShin H.D.-
dc.contributor.scopusid조인호(26643129000)-
dc.date.modifydate20180403152405-
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의과대학 > 의학과 > Journal papers
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