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Pharmacokinetics of itraconazole in diabetic rats

Title
Pharmacokinetics of itraconazole in diabetic rats
Authors
Lee U.Choi Y.H.Kim S.H.Lee B.K.
Ewha Authors
이병구
SCOPUS Author ID
이병구scopusscopus
Issue Date
2010
Journal Title
Antimicrobial Agents and Chemotherapy
ISSN
0066-4804JCR Link
Citation
vol. 54, no. 2, pp. 931 - 933
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
After intravenous or oral administration of 10 mg/kg itraconazole to rats with streptozotocin-induced diabetes mellitus and to control rats, the total area under the plasma concentration-time curve from time 0 to 24 h (AUC 0-24) for itraconazole and that for its metabolite, 7-hydroxyitraconazole, were similar between the two groups of rats. This may be explained by the comparable hepatic and intestinal intrinsic clearance rates for the disappearance of itraconazole and the formation of 7-hydroxyitraconazole in both groups of rats. Copyright © 2010, American Society for Microbiology. All Rights Reserved.
DOI
10.1128/AAC.01145-09
Appears in Collections:
약학대학 > 약학과 > Journal papers
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