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Label-free fluorescent real-time monitoring of adenylyl cyclase

Title
Label-free fluorescent real-time monitoring of adenylyl cyclase
Authors
Rhee H.-W.Kim K.-S.Han P.-L.Hong J.-I.
Ewha Authors
한평림김경심
SCOPUS Author ID
한평림scopus
Issue Date
2010
Journal Title
Bioorganic and Medicinal Chemistry Letters
ISSN
0960-894XJCR Link
Citation
vol. 20, no. 3, pp. 1145 - 1147
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
In cellular signaling, adenylyl cyclase plays a key role in the hydrolysis of ATP to cyclic AMP and pyrophosphate. Using a synthetic fluorescent chemosensor (PyDPA) which binds strongly to the pyrophosphate group, we have developed a label-free fluorescent real-time detection system for adenylyl cyclase. This assay would be the first adenylyl cyclase assay based on chemosensing the production of pyrophosphate. © 2009 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.bmcl.2009.12.018
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일반대학원 > 뇌·인지과학과 > Journal papers
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