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Nanosized titanium dioxide enhanced inflammatory responses in the septic brain of mouse

Title
Nanosized titanium dioxide enhanced inflammatory responses in the septic brain of mouse
Authors
Shin J.A.Lee E.J.Seo S.M.Kim H.S.Kang J.L.Park E.M.
Ewha Authors
이지희김희선박은미
SCOPUS Author ID
이지희scopus; 김희선scopus; 박은미scopus
Issue Date
2010
Journal Title
Neuroscience
ISSN
0306-4522JCR Link
Citation
vol. 165, no. 2, pp. 445 - 454
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Nanosized titanium dioxide (TiO 2) is used widely in various everyday products and can be applied to the medical field for diagnostic or therapeutic tools. However, its neurobiological responses have not been defined completely in the brain. To evaluate the acute inflammatory response to TiO 2 particles of two different sizes in normal and septic brains, male C57BL/6 mice were given intraperitoneal injections of fine (<1 μm) or ultrafine (21 nm) TiO 2, 30 min after vehicle or lipopolysaccaride (LPS). In the normal brain, neither fine nor ultrafine TiO 2 induced inflammation. However, in the brains of LPS-exposed mice, ultrafine TiO 2 significantly elevated proinflammatory cytokine interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) mRNAs, and IL-1β protein levels. Also ultrafine TiO 2 increased the levels of reactive oxygen species and activated microglia 24 h after LPS challenge. In BV2 microglial cells stimulated with LPS, ultrafine TiO 2 enhanced TNF-α production and augmented nuclear factor-kB binding activity. These findings suggest that nanosized TiO 2 promotes an exaggerated neuroinflammatory responses by enhancing microglial activation in the pre-inflamed brain, in part. © 2010 IBRO.
DOI
10.1016/j.neuroscience.2009.10.057
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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