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Syndecan-2 regulates cell migration in colon cancer cells through Tiam1-mediated Rac activation

Title
Syndecan-2 regulates cell migration in colon cancer cells through Tiam1-mediated Rac activation
Authors
Choi Y.Kim H.Chung H.Hwang J.-S.Shin J.-A.Han I.-O.Oh E.-S.
Ewha Authors
오억수김현정
SCOPUS Author ID
오억수scopus
Issue Date
2010
Journal Title
Biochemical and Biophysical Research Communications
ISSN
0006-291XJCR Link
Citation
vol. 391, no. 1, pp. 921 - 925
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Expression of the cell surface adhesion receptor syndecan-2 is known to be involved in the regulation of cancer cell migration. However, the molecular mechanism of syndecan-2-mediated cell migration remains unknown. Here we report that Rac contributes to the regulation of syndecan-2-mediated cancer cell migration. Overexpression of syndecan-2 enhanced migration and invasion of human colon adenocarcinoma cells Caco-2 and HCT116 cells. In parallel with the increased cell migration/invasion, syndecan-2 overexpression enhanced Rac activity, while dominant negative Rac (RacN17) diminished syndecan-2-mediated increased cancer cell migration. In addition syndecan-2 expression increased membrane localization of Tiam1 and syndecan-2-mediated cell migration/invasion of Caco-2 cells was diminished when Tiam1 levels were knocked-down with small inhibitory RNAs. Furthermore, oligomerization-defective syndecan-2 mutants failed to increase membrane localization of Tiam1, activation of Rac and subsequent cell migration of both Caco-2 and HCT116 cells. Taken together, these results suggest that syndecan-2 regulates cell migration of colon carcinoma cells through Tiam1-dependent Rac activation in colon cancer cells. © 2009 Elsevier Inc. All rights reserved.
DOI
10.1016/j.bbrc.2009.11.165
Appears in Collections:
자연과학대학 > 생명과학전공 > Journal papers
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