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dc.contributor.author홍영미*
dc.contributor.author조인호*
dc.date.accessioned2016-08-28T12:08:42Z-
dc.date.available2016-08-28T12:08:42Z-
dc.date.issued2010*
dc.identifier.issn0307-0565*
dc.identifier.otherOAK-6202*
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/220468-
dc.description.abstractBackground: Although the human adenovirus-36 (Ad-36) has been associated with obesity and related lipid disorders in the United States, this association has yet to be identified in other countries. Therefore, we tried to determine whether Ad-36 is associated with obesity or lipid disorders in Korean schoolchildren.Method:A total of 318 Korean schoolchildren aged 6-15 years, who participated in the Ewha Womans University Obesity Research Study, were selected for a community-based cohort study. Non-obese and obese were defined as body mass index (BMI) 85th and 95th percentiles of the Korean reference BMI-for-age curves, respectively, according to International Obesity Task Force definitions. The cutoff points for lipid disorders were modified from the age-modified standards of the National Cholesterol Education Program (NCEP)-Adult Treatment Panel (ATP) III metabolic syndrome criteria. The Ad-36 antibody was measured using a serum neutralization assay.Results:More obese participants than non-obese participants tested positive for the Ad-36 antibody (28.57 vs 13.56%, respectively; P0.0174). Within the obese group, the participants who tested positive for the Ad-36 antibody had higher levels of triglycerides (TG) and total cholesterol than those who tested negative for the Ad-36 antibody (P0.001). However, these associations were not present in the non-obese group. The unadjusted odds ratio (OR) for Ad-36 antibody positivity was greater in obese participants than non-obese participants (OR2.550, 95% confidence interval (CI): 1.154-5.633). However, this OR seemed to be nonsignificant when age, sex and lipid variables were included in the analysis (OR1.752, 95% CI: 0.763-4.020). The unadjusted OR for the elevated TG was significantly higher in participants who were Ad-36 antibody-positive than those who were Ad-36 antibody-negative (OR2.511, 95% CI: 1.448-4.353). This trend remained constant even after adjustment for age, sex and obesity (OR2.328, 95% CI: 1.296-4.181).Conclusion:Ad-36 seems to be strongly associated with lipid disorders in Korean schoolchildren regardless of obesity. © 2010 Macmillan Publishers Limited. All rights reserved.*
dc.languageEnglish*
dc.titleAssociation between human adenovirus-36 and lipid disorders in Korean schoolchildren*
dc.typeArticle*
dc.relation.issue1*
dc.relation.volume34*
dc.relation.indexSCI*
dc.relation.indexSCIE*
dc.relation.indexSCOPUS*
dc.relation.startpage89*
dc.relation.lastpage93*
dc.relation.journaltitleInternational Journal of Obesity*
dc.identifier.doi10.1038/ijo.2009.207*
dc.identifier.wosidWOS:000273519800013*
dc.identifier.scopusid2-s2.0-74249117320*
dc.author.googleNa H.-N.*
dc.author.googleHong Y.-M.*
dc.author.googleKim J.*
dc.author.googleKim H.-K.*
dc.author.googleJo I.*
dc.author.googleNam J.-H.*
dc.contributor.scopusid홍영미(35210025100;57327441600;55841904000;56063366100)*
dc.contributor.scopusid조인호(26643129000;56663841900)*
dc.date.modifydate20240123112949*
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의과대학 > 의학과 > Journal papers
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