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Efficacy and safety of tamsulosin for the treatment of non-neurogenic voiding dysfunction in females: A 8-week prospective study

Title
Efficacy and safety of tamsulosin for the treatment of non-neurogenic voiding dysfunction in females: A 8-week prospective study
Authors
Lee K.-S.Han D.H.Lee Y.-S.Choo M.-S.Yoo T.K.Park H.J.Yoon H.Jeong H.Lee S.J.Kim H.Park W.H.
Ewha Authors
윤하나
SCOPUS Author ID
윤하나scopus
Issue Date
2010
Journal Title
Journal of Korean Medical Science
ISSN
1011-8934JCR Link
Citation
vol. 25, no. 1, pp. 117 - 122
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Abstract
We evaluated the therapeutic effects of tamsulosin for women with non-neurogenic voiding dysfunction. Women who had voiding dysfunctions for at least 3 months were included. Inclusion criteria were age ≥18 yr, International Prostate Symptom Score (IPSS) of ≥15, and maximum flow rate (Qmax) of ≥12 mL/sec and/or postvoid residuals (PVR) of ≥150 mL. Patients with neurogenic voiding dysfunction or ana-tomical bladder outlet obstruction were excluded. All patients were classified accord-ing to the Blaivas-Groutz nomogram as having no or mild obstruction (group A) or moderate or severe obstruction (group B). After 8 weeks of treatment, treatment outcomes and adverse effects were evaluated. One hundred and six patients were evaluable (70 in group A, 36 in group B). After treatments, mean IPSS, bother scores, Qmax, PVR, diurnal and nocturnal micturition frequencies and scored form of the Bris-tol Female Lower Urinary Tract Symptoms questionnaire (BFLUTS-SF) were changed significantly. Eighty-nine patients (84%) reported that the treatment was beneficial. The proportion of patients reported that their bladder symptoms caused "moderate to many severe problems" were significantly decreased. No significant difference were observed between the groups in terms of IPSS, bother score, Qmax, PVR, mic-turition frequency, and BFLUTS-SF changes. Adverse effects related to medication were dizziness (n=3), de novo stress urinary incontinence (SUI) (n=3), aggravation of underlying SUI (n=1), fatigue (n=1). Tamsulosin was found to be effective in female patients with voiding dysfunction regardless of obstruction grade. © 2010 The Korean Academy of Medical Sciences.
DOI
10.3346/jkms.2010.25.1.117
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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