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Immunogenicity of haemophilus influenzae Type b Conjugate Vaccines in Korean Infants: A Meta-analysis

Title
Immunogenicity of haemophilus influenzae Type b Conjugate Vaccines in Korean Infants: A Meta-analysis
Authors
Lee H.Hahn S.Lee H.J.Kim K.-H.
Ewha Authors
김경효
SCOPUS Author ID
김경효scopus
Issue Date
2010
Journal Title
Journal of Korean Medical Science
ISSN
1011-8934JCR Link
Citation
vol. 25, no. 1, pp. 90 - 96
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Abstract
A meta-analysis was performed on the immunogenicity of Haemophilus influenzae type b (Hib) conjugate vaccines after 2 (2 and 4 months) and 3 doses (2, 4, and 6 months) in Korean infants. A database search of MEDLINE, KoreaMed, and Korean Medical Database was done. The primary outcome measure was the proportion of infants with anti-polyribosylribitol phosphate (PRP) concentrations ≥1.0 mg/mL. Eight studies including eleven trials were retrieved. One trial reported on the diphtheria toxoid conjugate vaccine (PRP-D) and 2 trials each on the mutant diphtheria toxin (PRP-CRM) and Neisseria meningitidis outer-membrane protein (PRP-OMP) conjugate vaccine. Heterogeneity in study designs between trials on PRP-CRM was noted and one trial reported on a monovalent and another on a combination PRPOMP vaccine. Thus, a meta-analysis was conducted only on the tetanus toxoid conjugate vaccine (PRP-T). After a primary series of 2 doses and 3 doses, 80.6% (95% confidence interval [CI]; 76.0-85.1%) and 95.7% (95% CI; 94.0-98.0%) of infants achieved an antibody level ≥1.0 mg/mL, respectively. The immunogenic response to the PRP-T vaccine was acceptable after a primary series of 3 doses and also 2 doses. A reduced number of doses as a primary series could be carefully considered in Korean infants. © 2010 The Korean Academy of Medical Sciences.
DOI
10.3346/jkms.2010.25.1.90
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의학전문대학원 > 의학과 > Journal papers
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