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PDE4 inhibitor upregulates PTH-induced osteoclast formation via CRE-mediated COX-2 expression in osteoblasts

Title
PDE4 inhibitor upregulates PTH-induced osteoclast formation via CRE-mediated COX-2 expression in osteoblasts
Authors
Park H.No A.L.S.M.Lee J.-M.Chen L.Lee S.Y.Lee D.-S.Yim M.
Ewha Authors
이수영
SCOPUS Author ID
이수영scopus
Issue Date
2010
Journal Title
FEBS Letters
ISSN
0014-5793JCR Link
Citation
vol. 584, no. 1, pp. 173 - 180
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
We investigated the interplay between parathyroid hormone (PTH) and phosphodiesterases (PDEs) in osteoblasts. PDE4 negatively regulated PTH-induced cAMP accumulation. PDE4 inhibitor enhanced PTH-induced osteoclast formation and RANKL mRNA expression, which is partially mediated by COX-2 mRNA expression. Two CRE sites in the COX-2 promoter were required for the increase in COX-2 transcription by PDE4 inhibitor, and the expression of a dominant-negative form of CREB abolished COX-2 mRNA expression in response to PDE4 inhibitor or PTH in osteoblasts. Taken together, our data indicate that PDE4 inhibitor promotes PTH-induced osteoclast formation partially via CRE-mediated COX-2 mRNA expression. © 2009 Federation of European Biochemical Societies.
DOI
10.1016/j.febslet.2009.11.043
Appears in Collections:
자연과학대학 > 생명과학전공 > Journal papers
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