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2,6-Dithienyl-4-furyl pyridines: Synthesis, topoisomerase I and II inhibition, cytotoxicity, structure-activity relationship, and docking study

Title
2,6-Dithienyl-4-furyl pyridines: Synthesis, topoisomerase I and II inhibition, cytotoxicity, structure-activity relationship, and docking study
Authors
Basnet A.Thapa P.Karki R.Choi H.Choi J.H.Yun M.Jeong B.-S.Jahng Y.Na Y.Cho W.-J.Kwon Y.Lee C.-S.Lee E.-S.
Ewha Authors
권영주
SCOPUS Author ID
권영주scopus
Issue Date
2010
Journal Title
Bioorganic and Medicinal Chemistry Letters
ISSN
0960-894XJCR Link
Citation
vol. 20, no. 1, pp. 42 - 47
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
For the development of novel antitumor agents, 2,6-dithienyl-4-furyl pyridine derivatives were prepared and evaluated for their topoisomerase I and II inhibitory activity as well as cytotoxicity against several human cancer cell lines. Among the 21 prepared compounds, compound 24 exhibited strong topoisomerase I inhibitory activity. In addition, a docking study with topoisomerase I and compound 24 was performed. © 2009 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.bmcl.2009.11.041
Appears in Collections:
약학대학 > 약학과 > Journal papers
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