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Effects of antioxidant supplements on cancer prevention: Meta-analysis of randomized controlled trials

Title
Effects of antioxidant supplements on cancer prevention: Meta-analysis of randomized controlled trials
Authors
Myung S.-K.Kim Y.Ju W.Choi H.J.Bae W.K.
Ewha Authors
주웅
SCOPUS Author ID
주웅scopus
Issue Date
2010
Journal Title
Annals of Oncology
ISSN
0923-7534JCR Link
Citation
vol. 21, no. 1, pp. 166 - 179
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Background: This meta-analysis aimed to investigate the effect of antioxidant supplements on the primary and secondary prevention of cancer as reported by randomized controlled trials. Methods: We searched Medline (PubMed), Excerpta Medica database, and the Cochrane Review in October 2007. Results: Among 3327 articles searched, 31 articles on 22 randomized controlled trials, which included 161 045 total subjects, 88 610 in antioxidant supplement groups and 72 435 in placebo or no-intervention groups, were included in the final analyses. In a fixed-effects meta-analysis of all 22 trials, antioxidant supplements were found to have no preventive effect on cancer [relative risk (RR) 0.99; 95% confidence interval (CI) 0.96-1.03). Similar findings were observed in 12 studies on primary prevention trials (RR 1.00; 95% CI 0.97-1.04) and in nine studies on secondary prevention trials (RR 0.97; 95% CI 0.83-1.13). Further, subgroup analyses revealed no preventive effect on cancer according to type of antioxidant, type of cancer, or the methodological quality of the studies. On the other hand, the use of antioxidant supplements significantly increased the risk of bladder cancer (RR 1.52; 95% CI 1.06-2.17) in a subgroup meta-analysis of four trials. Conclusions: The meta-analysis of randomized controlled trials indicated that there is no clinical evidence to support an overall primary and secondary preventive effect of antioxidant supplements on cancer. The effects of antioxidant supplements on human health, particularly in relation to cancer, should not be overemphasized because the use of those might be harmful for some cancer. © The Author 2009. Published by Oxford University Press on behalf of the European Society for Medical Oncology.
DOI
10.1093/annonc/mdp286
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의학전문대학원 > 의학과 > Journal papers
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