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Syndecan-2 functions as a docking receptor for pro-matrix metalloproteinase-7 in human colon cancer cells

Title
Syndecan-2 functions as a docking receptor for pro-matrix metalloproteinase-7 in human colon cancer cells
Authors
Ryu H.-Y.Lee J.Yang S.Park H.Choi S.Jung K.-C.Lee S.-T.Seong J.-K.Han I.-O.Oh E.-S.
Ewha Authors
오억수
SCOPUS Author ID
오억수scopus
Issue Date
2009
Journal Title
Journal of Biological Chemistry
ISSN
0021-9258JCR Link
Citation
vol. 284, no. 51, pp. 35692 - 35701
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Although elevated syndecan-2 expression is known to be crucial for the tumorigenic activity in colon carcinoma cells, how syndecan-2 regulates colon cancer is unclear. In human colon adenocarcinoma tissue samples, we found that both mRNA and protein expression of syndecan-2 were increased, compared with the neighboring normal epithelium, suggesting that syndecan-2 plays functional roles in human colon cancer cells. Consistent with this notion, syndecan-2-overexpressing HT-29 colon adenocarcinoma cells showed enhanced migration/invasion, anchorage-independent growth, and primary tumor formation in nude mice, paralleling their morphological changes into highly tumorigenic cells. In addition, our experiments revealed that syndecan-2 enhanced both expression and secretion of matrix metalloproteinase-7 (MMP-7), directly interacted with pro-MMP-7, and potentiated the enzymatic activity of pro-MMP-7 by activating its processing into the active MMP-7. Collectively, these data strongly suggest that syndecan-2 functions as a docking receptor for pro-MMP-7 in colon cancer cells. © 2009 by The American Society for Biochemistry and Molecular Biology, Inc.
DOI
10.1074/jbc.M109.054254
Appears in Collections:
자연과학대학 > 생명과학전공 > Journal papers
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