Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 서은경 | * |
dc.date.accessioned | 2016-08-28T12:08:35Z | - |
dc.date.available | 2016-08-28T12:08:35Z | - |
dc.date.issued | 2009 | * |
dc.identifier.issn | 0378-8741 | * |
dc.identifier.other | OAK-6099 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/220386 | - |
dc.description.abstract | Aim of study: The purpose of the present study was to examine the effects of daily administration of an aqueous extract of the dried, immature fruit of Poncirus trifoliata Raf. (Rutaceae) (PF-W) on body weight in rats. Materials and methods: PF-W was used in following experiments: 10-week-long measurement of body weight and food intake, in vitro pancreatic lipase activity assay, in vivo triglyceride concentration study, and measurement of intestinal transit rate. Results: A high dose of PF-W (200 mg/2 mL/animal/day, in aqueous solution) was administered intragastrically to rats for 10 weeks. PF-W suppressed body weight gain by 6%. However, administration of PF-W at a lower dose (20 mg/animal/day) did not reduce weight gain. Administration of low- or high-dose PF-W had no effect on food intake throughout the experimental period. Additional experiments revealed that the suppressive effect of PF-W on body weight gain was not related to pancreatic lipase activity. Moreover, co-administration of PF-W with a lipid emulsion did not reduce plasma triglyceride concentration. Of interest, the high dose of PF-W significantly increased the rate of intestinal transit, whereas oral administration of the lower dose did not. Control and PF-W-treated groups did not differ in hematological and serum biochemical parameters, or in relative organ weights after 10 weeks of high-dose PF-W administration. Conclusion: PF-W does not suppress body weight gain by interfering with fat absorption in a pancreatic lipase-dependent manner. The suppressive effect of PF-W on weight gain is likely due to the increased rate of intestinal transit, and the consequent reduction in nutrient absorption. Moreover, it appears that PF-W is relatively safe for long-term use. Taken together, the results of the present study suggest that long-term, daily administration of PF-W successfully suppressed body weight gain-apparently due to accelerated intestinal transit and not to interference with pancreatic lipase activity. Due to its apparent long-term safety, PF-W is a potential therapeutic agent for reduction of body weight in humans. © 2009 Elsevier Ireland Ltd. All rights reserved. | * |
dc.language | English | * |
dc.title | Long-term administration of an aqueous extract of dried, immature fruit of Poncirus trifoliata (L.) Raf. suppresses body weight gain in rats | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 126 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 294 | * |
dc.relation.lastpage | 299 | * |
dc.relation.journaltitle | Journal of Ethnopharmacology | * |
dc.identifier.doi | 10.1016/j.jep.2009.08.022 | * |
dc.identifier.wosid | WOS:000272368000016 | * |
dc.identifier.scopusid | 2-s2.0-70350394881 | * |
dc.author.google | Shim W.-S. | * |
dc.author.google | Back H. | * |
dc.author.google | Seo E.-K. | * |
dc.author.google | Lee H.-T. | * |
dc.author.google | Shim C.-K. | * |
dc.contributor.scopusid | 서은경(7005953758) | * |
dc.date.modifydate | 20240118144717 | * |