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Semantic dementia combined with motor neuron disease

Title
Semantic dementia combined with motor neuron disease
Authors
Kim S.H.Seo S.W.Go S.M.Suh M.K.Chin J.Jeong J.H.Na D.L.
Ewha Authors
정지향
SCOPUS Author ID
정지향scopus
Issue Date
2009
Journal Title
Journal of Clinical Neuroscience
ISSN
0967-5868JCR Link
Citation
vol. 16, no. 12, pp. 1683 - 1685
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Up to 20% of patients with behavioural variants of frontotemporal dementia (FTD) also have motor neuron disease (MND); conversely, this comorbidity is rare in patients with language variants of FTD. A few patients have been reported with semantic dementia (SD) combined with MND. However, these patients demonstrated the clinical features of MND in the advanced stage. We report a patient with SD who also demonstrated MND symptoms in an earlier stage of the disease. A 61-year-old man visited our memory disorder clinic as a result of language disturbance and dysarthria of 8 months duration and facial recognition impairment of 3 months duration. Neuropsychological tests revealed anomic aphasia, prosopagnosia, and decreased semantic fluency. A brain MRI revealed significant atrophies localized in both anterior temporal lobes with a greater prominence on the right side. Clinical examination and electrophysiological studies confirmed a diagnosis of MND 17 months after the onset of the disease. © 2009 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.jocn.2009.05.005
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의학전문대학원 > 의학과 > Journal papers
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