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Metallothionein-III provides neuronal protection through activation of nuclear factor-κB via the TrkA/phosphatidylinositol-3 kinase/Akt signaling pathway

Title
Metallothionein-III provides neuronal protection through activation of nuclear factor-κB via the TrkA/phosphatidylinositol-3 kinase/Akt signaling pathway
Authors
Kim H.G.Hwang Y.P.Han E.H.Choi C.Y.Yeo C.-Y.Kim J.Y.Lee K.Y.Jeong H.G.
Ewha Authors
여창열
SCOPUS Author ID
여창열scopus
Issue Date
2009
Journal Title
Toxicological Sciences
ISSN
1096-6080JCR Link
Citation
vol. 112, no. 2, pp. 435 - 449
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Metallothionein (MT)-III is associated with resistance to neuronal injury. However, the underlying mechanism for its effects is unclear. The present study investigated the mechanisms of MT-III protection of neuronal cells from hypoxia or DNA damage-induced cell death. MT-III reduced the hydrogen peroxide-or DNA damage-induced effects on neuronal cells, including the cell death, the activation of caspase-3 and -9, and the release of mitochondrial cytochrome c to the cytoplasm in a dose-dependent manner. MT-III also increased the activation of Akt, the phosphorylation and degradation of IκB, the nuclear translocation/accumulation and the transcriptional activity of nuclear factor-κB (NF-κB) in neuronal cells in a dose-dependent manner. The MT-III-induced antiapoptotic effects and increase in NF-κB activity were blocked by specific inhibitors of TrkA, phosphatidylinositol-3 kinase (PI3K), Akt, or NF-κB, indicating that MT-III provides neuronal protection by activating NF-κB through the TrkA/PI3K/Akt signaling pathway. © The Author 2009. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.
DOI
10.1093/toxsci/kfp230
Appears in Collections:
자연과학대학 > 생명과학전공 > Journal papers
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