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Dysfunction of retinal cell and optic nerve by continuous cerebroventricular infusion of glucosamine

Title
Dysfunction of retinal cell and optic nerve by continuous cerebroventricular infusion of glucosamine
Authors
Jang S.Han I.-O.Jun G.Oh S.
Ewha Authors
오세관
SCOPUS Author ID
오세관scopus
Issue Date
2009
Journal Title
Biomolecules and Therapeutics
ISSN
1976-9148JCR Link
Citation
vol. 17, no. 4, pp. 362 - 369
Indexed
SCIE; SCOPUS WOS scopus
Abstract
We have investigated the effect of glucosamine on the retinal cells after continuous infusion into cerebroventricle by using osmotic minipump to avoid peripheral effect. Continuous intracerebroventricular (i.c.v) infusion of glucosamine with the rate of 0.1 μmol/10 μl/hr for 7 days resulted in morphological changes of the optic nerve in electron microscopic level as well as morphological changes of the retina in light microscopic level. Retinal sections were immunostained for the detection of morphological changes of astrocytes. GFAP immunoreactivity appeared not only in the Muller cells but also many of the radial processes of Muller cells. The optic nerve showed deformed axon and slight lamellar separation of myelin sheath after continuous infusion of glucosamine in observing with electron microscope. Interestingly, vacuoles were observed in deformed axons and retinal layers were folded and detached. These results suggested that glucosamine plays a role in induction of morphological dysfunction in retina and optic nerves.
DOI
10.4062/biomolther.2009.17.4.362
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의학전문대학원 > 의학과 > Journal papers
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