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Synthesis of isoquinolinone-based tetracycles as poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors

Title
Synthesis of isoquinolinone-based tetracycles as poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors
Authors
Rhee H.-K.Lim S.Y.Jung M.-J.Kwon Y.Kim M.-H.Choo H.-Y.P.
Ewha Authors
박혜영권영주
SCOPUS Author ID
박혜영scopus; 권영주scopus
Issue Date
2009
Journal Title
Bioorganic and Medicinal Chemistry
ISSN
0968-0896JCR Link
Citation
vol. 17, no. 21, pp. 7537 - 7541
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The isoquinolinone-based tetracyclic compounds were designed and synthesized and their PARP-I inhibitory activity was evaluated. Most of synthesized compounds showed fairly good activity. Also the most active compound 6 showed its activity on potentiation of anticancer agents, temozolamide and etoposide, by 1.7 times, respectively. © 2009 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.bmc.2009.09.014
Appears in Collections:
약학대학 > 약학과 > Journal papers
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